Research Progress of Periodontitis Aggravating Rheumatoid Arthritis by Flora

doi:10.13701/j.cnki.kqyxyj.2023.05.003

Abstract

Abstract: Periodontitis is an immunoinflammatory disease with multifactorial involvement caused by plaque microorganisms. Rheumatoid arthritis is a systemic immune disease characterized by chronic inflammation and destroy in joint tissues. Both diseases share similarities in pathological processes and mechanisms of tissue destruction, including bone destruction, soft tissue inflammation, and the influence of the same environmental factors etc. In recent years, increasing attention has been put on the role of gut microbiota dysbiosis in systemic diseases, where periodontal pathogenic bacteria may enter the intestine through swallowing to affect gut microecology. Dysbiosis of gut microbiota can further aggravate the development of arthritis. The purpose of this review is to reveal the possible effects of gut microbiota on interactions between periodontitis and rheumatoid arthritis through the gut microbiota, as well as the related mechanism. Hopefully, this review will identify new insights on the relationship between periodontitis and rheumatoid arthritis.

Key words: periodontitis, rheumatoid arthritis, gut microbiota

LIU Rong, YANG Kun. Research Progress of Periodontitis Aggravating Rheumatoid Arthritis by Flora[J]. Journal of Oral Science Research, 2023, 39(5): 392-395.

References

[1] Konenč B, Chobodová P, Janko J, et al. The effect of melatonin on periodontitis [J]. Int J Mol Sci, 2021, 22(5):2390.
[2] Kapila YL. Oral health's inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions [J]. Periodontol 2000, 2021, 87(1):11-16.
[3] 由林,周瑞平,郭丽.16SrRNA基因检测技术在牙周病患者的口腔微环境研究的应用及诊断探索[J].口腔医学研究,2021,37(6):574-578.
[4] Rantapää Dahlqvist S, Andrade F. Individuals at risk of seropositive rheumatoid arthritis: the evolving story [J]. J Intern Med, 2019, 286(6):627-643.
[5] Gómez-Bañuelos E, Mukherjee A, Darrah E, et al. Rheumatoid Arthritis-associated mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans [J]. J Clin Med, 2019, 8(9):1309.
[6] Scherer HU, Häupl T, Burmester GR. The etiology of rheumatoid arthritis [J]. J Autoimmun, 2020, 110:102400.
[7] Bodkhe R, Balakrishnan B, Taneja V. The role of microbiome in rheumatoid arthritis treatment [J]. Ther Adv Musculoskelet Dis, 2019, 11:1759720x19844632.
[8] Qiao Y, Wang Z, Li Y, et al. Rheumatoid arthritis risk in periodontitis patients: A systematic review and meta-analysis [J]. Joint Bone Spine, 2020, 87(6):556-564.
[9] Nguyen VB, Nguyen TT, Huynh NC, et al. Effects of non-surgical periodontal treatment in rheumatoid arthritis patients: A randomized clinical trial [J]. Dent Med Probl, 2021, 58(1):97-105.
[10] Arévalo-Caro C, Romero-Sánchez C, Garavito-Rodríguez E. Relation between anti-Porphyromonas gingivalis antibody titers and HLA-DRB1 neutral alleles in individuals with rheumatoid arthritis [J]. Acta Odontol Scand, 2022, 80(2):131-139.
[11] Sato K, Takahashi N, Kato T, et al. Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system [J]. Sci Rep, 2017, 7(1):6955.
[12] Rodríguez-Lozano B, González-Febles J, Garnier-Rodríguez JL, et al. Association between severity of periodontitis and clinical activity in rheumatoid arthritis patients: a case-control study [J]. Arthritis Res Ther, 2019, 21(1):27.
[13] González-Febles J, Rodríguez-Lozano B, Sánchez-Piedra C, et al. Association between periodontitis and anti-citrullinated protein antibodies in rheumatoid arthritis patients: a cross-sectional study [J]. Arthritis Res Ther, 2020, 22(1):27.
[14] Weyand CM, Goronzy JJ. The immunology of rheumatoid arthritis [J]. Nat Immunol, 2021, 22(1):10-18.
[15] de Molon RS, Rossa C Jr, Thurlings RM, et al. Linkage of periodontitis and rheumatoid arthritis: Current evidence and potential biological interactions [J]. Int J Mol Sci, 2019, 20(18):4541.
[16] Ishikawa Y, Terao C. The impact of cigarette smoking on risk of rheumatoid arthritis: A narrative review [J]. Cells, 2020, 9(2):475.
[17] Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: dynamic communities and host interactions [J]. Nat Rev Microbiol, 2018, 16(12):745-759.
[18] Gabarrini G, Grasso S, van Winkelhoff AJ, et al. Gingimaps: Protein localization in the oral pathogen Porphyromonas gingivalis [J]. Microbiol Mol Biol Rev, 2020, 84(1):e00032-19.
[19] Jenning M, Marklein B, Ytterberg J, et al. Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection-a missing link for ACPA production [J]. Ann Rheum Dis, 2020, 79(9):1194-1202.
[20] Cheng Z, Do T, Mankia K, et al. Dysbiosis in the oral microbiomes of anti-CCP positive individuals at risk of developing rheumatoid arthritis [J]. Ann Rheum Dis, 2021, 80(2):162-168.
[21] Zhou N, Zou F, Cheng X, et al. Porphyromonas gingivalis induces periodontitis, causes immune imbalance, and promotes rheumatoid arthritis [J]. J Leukoc Biol, 2021, 110(3):461-473.
[22] Konig MF, Giles JT, Teles RP, et al. Response to comment on "Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis" [J]. Sci Transl Med, 2018, 10(433):eaao3031.
[23] de Oliveira RCG, Gardev E, Shaddox LM. Dysbiotic relationship between arthritis and the oral-gut microbiome. A critical review [J]. J Periodontal Res, 2022, 57(4):711-723.
[24] Lourenço TGB, Spencer SJ, Alm EJ, et al. Defining the gut microbiota in individuals with periodontal diseases: an exploratory study [J]. J Oral Microbiol, 2018, 10(1):1487741.
[25] Wu L, Han J, Nie JY, et al. Alterations and correlations of gut microbiota and fecal metabolome characteristics in experimental periodontitis rats [J]. Front Microbiol, 2022, 13:865191.
[26] Bao J, Li L, Zhang Y, et al. Periodontitis may induce gut microbiota dysbiosis via salivary microbiota [J]. Int J Oral Sci, 2022, 14(1):32.
[27] Kitamoto S, Nagao-Kitamoto H, Jiao Y, et al. The intermucosal connection between the mouth and gut in commensal pathobiont-driven colitis [J]. Cell, 2020,182(2):447-462.e14.
[28] Moore RE, Townsend SD. Temporal development of the infant gut microbiome [J]. Open Biol, 2019, 9(9):190128.
[29] Alpizar-Rodriguez D, Lesker TR, Gronow A, et al. Prevotella copri in individuals at risk for rheumatoid arthritis [J]. Ann Rheum Dis, 2019, 78(5):590-593.
[30] Cheng M, Zhao Y, Cui Y, et al. Stage-specific roles of microbial dysbiosis and metabolic disorders in rheumatoid arthritis [J]. Ann Rheum Dis, 2022, 81(12):1669-1677.
[31] Jubair WK, Hendrickson JD, Severs EL, et al. Modulation of inflammatory arthritis in mice by gut microbiota through mucosal inflammation and autoantibody generation [J]. Arthritis Rheumatol, 2018, 70(8):1220-1233.
[32] Doonan J, Tarafdar A, Pineda MA, et al. The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis [J]. Nat Commun, 2019, 10(1):1554.
[33] Aa LX, Fei F, Qi Q, et al. Rebalancing of the gut flora and microbial metabolism is responsible for the anti-arthritis effect of kaempferol [J]. Acta Pharmacol Sin, 2020, 41(1):73-81.
[34] Feng YK, Wu QL, Peng YW, et al. Oral P. gingivalis impairs gut permeability and mediates immune responses associated with neurodegeneration in LRRK2 R1441G mice [J]. J Neuroinflammation, 2020, 17(1):347.
[35] Yamazaki K, Kato T, Tsuboi Y, et al. Oral pathobiont-induced changes in gut microbiota aggravate the pathology of nonalcoholic fatty liver disease in mice [J]. Front Immunol, 2021, 12:766170.
[36] Lorenzo D, GianVincenzo Z, Carlo Luca R, et al. Oral-gut microbiota and arthritis: Is there an evidence-based axis? [J]. J Clin Med, 2019, 8(10):0.
[37] Kitamura K, Shionoya H, Suzuki S, et al. Oral and intestinal bacterial substances associated with disease activities in patients with rheumatoid arthritis: A cross-sectional clinical study [J]. J Immunol Res, 2022, 2022:6839356.
[38] Muñoz-Atienza E, Flak MB, Sirr J, et al. The P. gingivalis autocitrullinome is not a target for ACPA in early rheumatoid arthritis [J]. J Dent Res, 2020, 99(4):456-462.
[39] Flak MB, Colas RA, Muñoz-Atienza E, et al. Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis [J]. JCI Insight, 2019, 4(13):e125191.
[40] Matei DE, Menon M, Alber DG, et al. Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease [J]. Med, 2021, 2(7):864-883.e9.
[41] du Teil Espina M, Gabarrini G, Harmsen HJM, et al. Talk to your gut: the oral-gut microbiome axis and its immunomodulatory role in the etiology of rheumatoid arthritis [J]. FEMS Microbiol Rev, 2019, 43(1):1-18.