Abstract: Gardner's syndrome is an autosomal dominant genetic disease. It is rare in clinical practice. The main clinical symptoms are colorectal polyps, soft tissue masses, and osteoma. Therefore, some patients are often treated in the oral and maxillofacial surgery department for maxillofacial osteoma. Due to the high incidence of multiple polyps of the rectum colon in this disease, oral imaging examination combined with patient history is more helpful for early diagnosis. We report two cases of Gardner syndrome diagnosed for the first time in our department with mandibular osteoma as the chief complaint.

Key words: Gardner's syndrome, osteoma of jaw, adenomatous polyposis coli