FPS-ZM1 Rescues the Inflammatory Response of hPDLFs Caused by High Glucose via Inhibition of RAGE

doi:10.13701/j.cnki.kqyxyj.2017.11.006

Abstract

Abstract: Objective: To observe the effect of FPS-ZM1 on IL-6 and TNF-α expression of human periodontal ligament fibroblasts (hPDLFs) cultured in high glucose. Methods: hPDLFs were primarily cultured and exposed to either low glucose (5.5mmol/L) or high glucose (25mmol/L). Under high glucose, the expression of RAGE was measured by Western-blot. The gene and protein expressions of IL-6 and TNF-α were measured by RT-PCR and ELISA under high glucose with various concentration of FPS-ZM1. Results: High glucose could enhance RAGE expression and the inflammatory response of hPDLFs, which was inverted by RAGE inhibitor FPS-ZM1. Conclusion: FPS-ZM1 can rescue the inflammatory response of hPLDFs caused by high glucose.

Key words: hPDLFs, RAGE inhibitor, High glucose, Inflammatory response

CLC Number:

R781.4

ZHAN Dan-ting, DING Nong-le, ZHANG Yun-shui, ZHANG Hui, GUO Ling. FPS-ZM1 Rescues the Inflammatory Response of hPDLFs Caused by High Glucose via Inhibition of RAGE[J]. Journal of Oral Science Research, 2017, 33(11): 1156-1160.

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