Effects of RAGE Inhibitor FPS-ZM1 on hPDLFs Proliferation and Migration in High Glucose.

doi:10.13701/j.cnki.kqyxyj.2017.12.005

Abstract

Abstract: Objective: To investigate the RAGE inhibition by FPS-ZM1 on proliferation and migration of human periodontal ligament fibroblasts (hPDLFs) in high glucose environment. Methods: Western-blot was used to detect the expression of RAGE in hPDLFs in high glucose environment. Different concentrations of FPS-ZM1 were added to cultivate hPDLFs cells in vitro, CCK-8 assay was used to determine the cell proliferation, and the scratch experiment was used to detect the migration ability of cells. Results: The expression of RAGE protein in hPDLFs cells cultured in high glucose group was significantly higher than that in low glucose group. FPS-ZM1 promoted the proliferation and migration ability of hPDLFs, and the optimal concentration is 250 nmol/L. Conclusion: FPS-ZM1 can promote the proliferation and migration abilities of hPDLFs in vitro.

Key words: hPDLFS, FPS-ZM1 , Proliferation, Migration

CLC Number:

R781.4

GUO Ling, ZHANG Yuan-shui, ZHAN Dan-ting, LI Wang-yang, DING Nong-le.. Effects of RAGE Inhibitor FPS-ZM1 on hPDLFs Proliferation and Migration in High Glucose.[J]. Journal of Oral Science Research, 2017, 33(12): 1258-1261.

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