Changes of Microarchitecture of Alveolar Bone in Experimental Periodontitis in Rats

doi:10.13701/j.cnki.kqyxyj.2017.11.008

Abstract

Abstract: Objective: To study the changes of the microarchitecture of alveolar bone in the experimental periodontitis in rats. Methods: Fourteen 3-month-old Sprague-Dawley rats were used to establish periodontitis model by ligaturing the left maxillary 1st molar (PER), and the right maxillary 1st molar was used as control (CON). The rats were sacrificed respectively 4 weeks and 8 weeks later. The maxilla was analyzed by Micro-CT scanning. All statistical analysis was performed with SPSS. Results: The probing depth in PER group increased in comparison to CON group at both 4 and 8 weeks. The alveolar bone of CON group was compacted with plate-like trabecular, while the alveolar bone of PER group become porotic with rod-like trabecular. When compared with corresponding CON group, BMD, BV/TV, and Tb.Th. of alveolar bone significantly decreased in PER group at both 4 and 8 weeks. BMD, BV/TV, and Tb.Th. in 8-week PER group decreased compared with 4-week PER group. Tb.N and Tb.Sp. in 8-week PER group increased in compared with both CON group and 4-week PER group. Conclusion: Periodontitis could induce bone loss and deterioration of trabeculae of alveolar bone. The deterioration might be aggravated by the extended duration.

Key words: Periodontitis, Alveolar bone, Micro-CT, Microarchitecture

CLC Number:

R781.4

CHENG Jing-yi, ZHANG Yun, CHENG Cai-yun, CHENG Lan, ZHANG Xiu-yin. Changes of Microarchitecture of Alveolar Bone in Experimental Periodontitis in Rats[J]. Journal of Oral Science Research, 2017, 33(11): 1165-1168.

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