Curative Effect of Endogenous Resolvin D1 on Periodontitis in Rats

doi:10.13701/j.cnki.kqyxyj.2017.12.008

Abstract

Abstract: Objective: To investigate the effect of resolvin D1 (RvD1) on periodontitis in rat. Methods: The models of periodontitis were established in eighteen rats, which were randomly divided into 3 groups, experimental group A (100ng/ml RvD1), experimental group B (50ng/ml RvD1), and control group C (saline). Intervention was provided by systemic injection from the tail vein. Clinical parameters and morphological analysis were measured at different time intervals after treatment. All statistical analysis was performed using the SPSS 21.0 statistical package. Results: After 1 week of treatment, periodontal pocket depth (PD), gingival index (GI), tooth mobility (TM), and alveolar bone loss (ABL) in experimental group A (100ng/ml RvD1) were lower than those in the control group (P<0.05). For experimental group B (50ng/ml RvD1), only GI and TM showed statistical significance when compared with control group (P<0.05). PD in both experimental groups was similar. Conclusion: RvD1 might be used to prevent alveolar bone resorption in periodontitis.

Key words: Resolvin D1 , Periodontitis , Animal model

CLC Number:

R739.8

TANG Cai-jin, ZENG Qi-xin, FAGN Mei-fei, MA Fei, TAO Ren-Chuan, Niyukty Arjal. Curative Effect of Endogenous Resolvin D1 on Periodontitis in Rats[J]. Journal of Oral Science Research, 2017, 33(12): 1270-1273.

References

[1] Kohli P, Levy BD. Resolvins and protectins: mediating solutions to inflammation [J]. British journal of pharmacology,2009,158(4)∶960-971
[2] Schwab JM, Chiang N, Arita M, et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes [J]. Nature,2007,447(7146)∶869-874
[3] Mustafa M, Zarrough A, Bolstad AI, et al. Resolvin D1 protects periodontal ligament [J]. American journal of physiology Cell physiology,2013,305(6)∶C673-679
[4] Steffens JP, Herrera BS, Coimbra LS, et al. Testosterone regulates bone response to inflammation [J]. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,2014,46(3)∶193-200
[5] 刘飞,张林,肖刚,等.生命早期负性应激对大鼠实验性牙周炎的影响[J].口腔医学研究,2017,33(3)∶244-248
[6] Cianci E, Recchiuti A, Trubiani O, et al. Human Periodontal Stem Cells Release Specialized Proresolving Mediators and Carry Immunomodulatory and Prohealing Properties Regulated by Lipoxins [J]. STEM CELLS Translational Medicine,2016,5(1)∶20-32
[7] Damgaard C, Kantarci A, Holmstrup P, et al. Porphyromonas gingivalis-induced production of reactive oxygen species, tumor necrosis factor-alpha, interleukin-6, CXCL8 and CCL2 by neutrophils from localized aggressive periodontitis and healthy donors: modulating actions of red blood cells and resolvin E1 [J]. Journal of periodontal research,2017,52(2)∶246-254
[8] Fredman G, Oh SF, Ayilavarapu S, et al. Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1 [J]. PloS one,2011,6(9)∶e24422
[9] Fredman G, Serhan CN. Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution [J]. The Biochemical journal,2011,437(2)∶185-197
[10] Lee CT, Teles R, Kantarci A, et al. Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis [J]. Journal of immunology,2016,197(7)∶2796-806
[11] Maekawa T, Hosur K, Abe T, et al. Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3beta-C/EBPbeta pathway [J]. Nature communications,2015,6∶8272

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