Analysis of Risk Factors of Chemotherapy-induced Oral Mucositis

doi:10.13701/j.cnki.kqyxyj.2019.08.021

Abstract

Abstract: Objective: To explore the risk factors of oral mucositis induced by chemotherapy. Methods: Through retrospective analyzing the clinical data of 205 cases of malignant tumor patients who performed chemotherapy, we discussed the correlation between chemotherapy stomatitis and patient’s age, sex, tumor type, containing fluorouracil (5-FU) way of chemotherapy, the strength of chemotherapy, chemotherapy cycle, oral acute or chronic disease, oral hygiene status, the number of neutrophils, hemoglobin level, and whether associated with diabetes. Results: Univariate analysis showed that there were statistically significant differences in chemotherapy, intensity of chemotherapy, duration of chemotherapy, oral diseases, oral hygiene, and neutrophil levels. Further multivariate analysis showed that the intensity of chemotherapy drugs (β=1.099, P<0.05), duration of chemotherapy (β=0.964, P<0.05), mode of chemotherapy (β=1.100, P<0.05), acute and chronic diseases of the oral cavity (β=1.180, P<0.05), and number of neutrophils (β=1.050, P<0.05) were the main factors leading to chemotherapeutic stomatitis. Conclusion: The intensity and cycle of chemotherapeutic drugs, chemotherapy regimens, oral acute and chronic diseases, and neutrophil levels were risk factors for chemotherapeutic stomatitis.

Key words: chemotherapy, oral mucositis, risk factors, retrospective study

LI Qingfu, LI Xiqing, JIANG Li, MA Xin. Analysis of Risk Factors of Chemotherapy-induced Oral Mucositis[J]. Journal of Oral Science Research, 2019, 35(8): 810-813.

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