Analysis of Clinical and Pathological Factors Affecting Prognosis of Patients in Major Salivary Glands Adenoid Cystic Carcinoma Based on SEER Database

doi:10.13701/j.cnki.kqyxyj.2020.02.018

Journal of Oral Science Research ›› 2020, Vol. 36 ›› Issue (2): 167-171.DOI: 10.13701/j.cnki.kqyxyj.2020.02.018

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Analysis of Clinical and Pathological Factors Affecting Prognosis of Patients in Major Salivary Glands Adenoid Cystic Carcinoma Based on SEER Database

ZOU Huihui^{1, 2}, XU Wenguang^{1, 2}, YIN Xiteng^{1, 2}, HAN Wei^{1, 2}, JIANG Linlin^3*

1. Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China;
2. Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210093, China;
3. Department of Medical Oncology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing 210003, China

Received:2019-05-22 Online:2020-02-28 Published:2020-04-24

Abstract

Abstract: Objective: investigate the clinicopathological features affecting patients with adenoid cystic carcinoma based on a public database SEER (Surveillance Epidemiology, and End Results). Methods: Data from patients with adenoid cystic carcinoma in major salivary gland from 2004 to 2015 were downloaded from the SEER public database. Both univariate and multivariate COX regression analysis were applied to investigate the key clinicopathological parameters associated with prognosis. Results: A total of 428 ACC patient' data with complete clinical follow-up information were included in the study. The multivariate COX regression analysis proved that tumor site, T stage, N stage, M stage, and histological grade were independent factors affecting the patients prognosis (P<0.05). Conclusion: Tumor site, T stage, N stage, M stage, and histological grade were independent factors affecting the prognosis which would be a great assist for the clinical treatment.

Key words: major salivary gland, adenoid cystic carcinoma, prognostic factors, SEER database

ZOU Huihui, XU Wenguang, YIN Xiteng, HAN Wei, JIANG Linlin. Analysis of Clinical and Pathological Factors Affecting Prognosis of Patients in Major Salivary Glands Adenoid Cystic Carcinoma Based on SEER Database[J]. Journal of Oral Science Research, 2020, 36(2): 167-171.

References

[1] Dubal PM, Unsal AA, Chung SY, et al. Population-based trends in outcomes in adenoid cystic carcinoma of the oral cavity [J]. Am J Otolaryngol, 2016, 37(5): 398-406.
[2] 房欢欢,钟旖,万林忠.涎腺腺样囊性癌嗜神经侵袭相关神经营养因子的研究进展[J].口腔生物医学,2019,10(1):54-57.
[3] 邵喆,江希松,宋凯,等.腺样囊性癌嗜神经侵袭体外模型的建立[J].口腔医学研究,2014,30(3):209-211.
[4] Wen J, Chen J, Chen D, et al. Evaluation of the prognostic value of surgery and postoperative radiotherapy for patients with thymic neuroendocrine tumors: A propensity-matched study based on the SEER database[J]. Thorac Cancer, 2018,9(12):1603-1613.
[5] Coca-Pelaz A, Rodrigo JP, Bradley PJ, et al. Adenoid cystic carcinoma of the head and neck-An update[J]. Oral Oncol, 2015, 51(7): 652-661.
[6] He S, Li P, Zhong Q, et al. Clinicopathologic and prognostic factors in adenoid cystic carcinoma of head and neck minor salivary glands: A clinical analysis of 130 cases [J]. Am J Otolaryngol, 2017, 38(2): 157-162.
[7] 许宁,朱恩新,张茜,等.Cyclin D1和Ki67与涎腺腺样囊性癌发生及预后的相关性研究[J].口腔医学研究,2010,26(1):22-25.
[8] Bobati SS, Patil BV, Dombale VD. Histopathological study of salivary gland tumors [J]. J Oral Maxillofac Pathol, 2017, 21(1): 46-50.
[9] Cao C, Ge M, Chen X, et al. Clinical outcomes and prognostic factors of salivary gland adenoid cystic carcinomas: a case control study[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2017, 123(5): 531-535.
[10]da Cruz Perez DE, de Abreu Alves F, Nobuko Nishimoto I, et al. Prognostic factors in head and neck adenoid cystic carcinoma[J]. Oral Oncol, 2006, 42(2): 139-146.
[11]陈琦.影响腺样囊性癌预后的多因素回归分析[J].国际口腔医学杂志,2015,42(5):531-534.

Analysis of Clinical and Pathological Factors Affecting Prognosis of Patients in Major Salivary Glands Adenoid Cystic Carcinoma Based on SEER Database

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