Abstract: Objective: To investigate the efficacy of excision of submandibular gland and its associated Wharton's duct in the treatment of sialolithiasis. Methods: A total of sixty patients with sialolithiasis underwent excision of submandibular gland via a transcervical incision combined with or without surgical resection of its associated Wharton's duct via an intraoral incision. The therapeutic effects and postoperative complications were evaluated. Results: Mean length of the resected Wharton's duct was significantly shorter in the traditional surgery group [(2.33±0.42) cm] than in the modified surgery group [(4.31±0.43) cm]. Ratio of sialoliths recurrence was significantly higher in the traditional surgery group (2/30) than in the modified surgery group (0/30). However, there was no significant difference in the postoperative complications such as lingual never damage, swallowing pain, hypoglossal gland cyst, chronic sublinguitis, hypoglossal never injury, facial nerve injury, and inflammation of the residual Wharton's duct between two groups. Conclusion: Excision of the submandibular gland and its associated Wharton's duct was safe and feasible for the treatment of sialolithiasis, which may be applied as an option for the patients with high risk of sialoliths recurrence

Key words: sialolithiasis, submandibular gland, Wharton's duct, complication