Protective Effect of Erythropoietin against Salivary Gland Radiation Injury.

doi:10.13701/j.cnki.kqyxyj.2017.06.006

Abstract

Abstract: Objective: To investigate the protection of erythropoietin (EPO) against the radiation-induced salivary glands injury in rats. Methods: Thirty rats were divided into 3 groups, which were the control group, radiation group (IR+saline), and treatment (IR+EPO) group. The rat's head and neck received a single dose of 15Gy. EPO treatment via intraperitoneal was started 30min before irradiation and then was repeated every 48h for the first 2 weeks at dose of 3000IU/Kg at the end of irradiation. The salivary flow rate was assessed after 90 days and then the submandibular was removed to make Paraffin for HE staining, Masson staining, and immunohistochemical staining to observe the expression of PCNA. Results: The IR+EPO group's salivary secretion was greater than that of IR+saline group and exhibited less injury of gland tissue than the IR+saline group. The control group showed a higher PCNA positive cell rate than the IR+saline group. Conclusion: EPO has a good protective effect against the radiation-induced salivary gland injury.

Key words: EPO , Radiation protection, Rats , Submandibular gland

CLC Number:

R816.98

WANG Yue, SUN Bin, MA Xiao-zhou, LIU Kang, DU Bao-xia, YU Yang, ZHANG Wei.. Protective Effect of Erythropoietin against Salivary Gland Radiation Injury.[J]. Journal of Oral Science Research, 2017, 33(6): 601-604.

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