Abstract: Objective: To evaluate the effects of strontium ranelate on experimental periodontitis rats. Methods: Fifty 3-month-old male SD rats were randomly divided into five groups (10 rats/group): normal group (group A), periodontitis group (group B), periodontitis with locally treating group (group C), periodontitis with strontium ranelate treating group (group D), and periodontitis with locally treating + strontium ranelate treating group (group E). Periodontitis model was established in group B, C, D, and E. Group C was treated by local drug application. Group D was treated by intragastric administration with strontium ranelate. Group E was treated by local drug application and intragastric administration. The rats were sacrificed after 8 weeks of periodontal treatment and drug treatment. The number of osteoblasts and osteoclasts in per periodontal unit area was counted. Tartrate resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) staining were performed to evaluate the alveolar bone metabolism. Results: After local treatment and strontium ranelate treatment, the inflammation of periodontal tissue was reduced, and periodontal pockets became shallower, the osteoclasts stained with TRAP in per unit area decreased significantly, and the osteoblasts stained with ALP increased significantly. Conclusion: Strontium ranelate, as a therapeutic agent for osteoporosis, can also have a certain effect on the treatment of experimental periodontitis, and provide new idea for the comprehensive treatment of periodontitis.

Key words: periodontitis, strontium ranelate, acid phosphatase, alkaline phosphatase, osteoblast, osteoclast