Effects of Low Intensity Laser Combined with FM-SRP on Levels of TGF-β1, t-AP, and PAI-1 in Gingival Crevicular Fluid of Patients with Chronic Periodontitis

doi:10.13701/j.cnki.kqyxyj.2022.09.019

Abstract

Abstract: Objective: To explore the effects of low intensity laser combined with FM-SRP on the levels of TGF-β1, t-AP, and PAI-1 in gingival crevicular fluid of patients with chronic periodontitis. Methods: In this prospective study, 28 patients with chronic periodontitis admitted to our hospital from October 2019 to August 2021 were selected and divided into observation group and control group by random number table method. Patients in the control group received FM-SRP treatment, and patients in the observation group received FM-SRP treatment supplemented by low-intensity laser. Pain score, periodontal clinical indicators, inflammatory factors, vascular endothelial function, GCF transforming growth factor, t-AP, PAI-1, and adverse reactions were compared between two groups. Results: The pain score in the observation group was significantly lower than that of control group at 3d after treatment. After treatment, gingival bleeding index, probing depth, clinical attachment loss, and plaque index in the observation group, were significantly lower than those in the control group. Interleukin-8, matrix metalloproteinase-7, and high mobility group protein B1 in the observation group were significantly lower than those in the control group. The FMD and NMD in the observation group were significantly higher than those in the control group ingival crevice fluid transforming growth factor β1 and t-AP in the observation group were significantly higher than those in the control group, and the PAI-1 of gingival crevicular fluid in the observation group was significantly lower than that in the control group. Conclusion: Low intensity laser combined with FM-SRP in the treatment of chronic periodontitis can effectively relieve pain, eliminate inflammation, improve vascular endothelial function, improve periodontal status indicators, and may be associated with the reduction of gingival crevicular fluid transforming growth factor and t-AP and improvement of PAI-1 level, which is safe and worthy of clinical promotion.

Key words: chronic periodontitis, low intensity laser, full-mouth scaling and root planning, transforming growth factor β1, tissue plasminogen activator, plasminogen activators-1

YAO Lingling, HUANG Manying, XIONG Jiwen. Effects of Low Intensity Laser Combined with FM-SRP on Levels of TGF-β1, t-AP, and PAI-1 in Gingival Crevicular Fluid of Patients with Chronic Periodontitis[J]. Journal of Oral Science Research, 2022, 38(9): 887-891.

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