Abstract: Objective: To study the clinical effect of sequential periodontal treatment on chronic periodontitis patients with mouth breathing and malocclusion deformity in anterior tooth region. Methods: Ten chronic periodontitis patients with mouth breathing and malocclusion deformity in anterior tooth region were selected in the Department of Periodontology and Oral Mucosa, Stomatological Hospital of Dalian from September 2007 to September 2008.These patients received sequential periodontal treatment for more than 5 years, including periodontal initial therapy, periodontal surgical therapy, orthodontic treatment, and periodontal supportive therapy. Clinical parameters of probing depth (PD), clinical attachment level (CAL), tooth mobility (TM) and bleeding on probing (BOP) were recorded by Florida electronic probe in anterior tooth region at baseline and 1-3 years after orthodontic treatment, and then analysis was carried out.Panoramic tomogram intraoral radiography was detected at baseline and 1-3 years after orthodontic treatment. Results: PD and CAL were decreased 1-3 years after orthodontic treatment, the positive sites of BOP were reduced, and the statistical differences were detected (P<0.01). TM was improved, however, not significant. Conclusion: For chronic periodontitis patients with mouth breathing and malocclusion deformity in anterior tooth region, the more than 5 years clinical treatment of sequential periodontal is effective and stable.