Abstract: Objective:To investigate therhore effective acid-etching methods on the adhesion of mild-to-moderate dental fluorosis enamel. Methods: Randomized control trials (RCTs) or controlled clinical trials (CCTs) about enamel bonding of dental fluorosis were searched manually or by computer in 8 electronic databases without any time, region and languages limits. According to inclusion/exclusion criteria, related data were extracted, the risk of biases were evaluated, and the qualitative and quantitative analysis of the included studies were performed. Results: Eightstudies were included.The results of the Meta-analysis showed thatWMD(total-etching: mild-to-moderate dental fluorosis/normal)=-0.00,95%CI[-0.30,0.29];WMD(self-etching: mild-to-moderate dental fluorosis/normal)=-0.80,95%CI[-1.07,-0.53];WMD(mild-to-moderate dental fluorosis: self/total)=-6.08,95%CI[-7.70,-4.46]. There was no statistical difference of shear bond strength(SBS) of total-etching between mild-to-moderate dental fluorosis and normal teeth. The SBS of self-etching for mild-to-moderate dental fluorosis was lower than normal teeth.The SBS of total-etching was higher than that of self-etching. Conclusion: The SBS of total-etching shows no difference or even higher than the SBS of self-etching in enamel adhesion of mild-to-moderate dental fluorosis in the same condition.