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28 November 2015, Volume 31 Issue 11 Previous Issue    Next Issue

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Effect of Chloroquine on the Proliferation of Rats Bone Marrow Mesenchymal Stem Cells Irritated by MT01. LI Wei-ting, LI Bo, DING Zi-qing, CUI Ye, GAO Han, LIU Yin, SHEN Yu-qin. 2015, 31(11): 1061-1063.  DOI: DOI Abstract ( 158 )   PDF (1058KB) ( 187 )   Objective: To confirm that MT01 may influence the biological properties of bone marrow mesenchymal stem cells (BMSCs) via endosome by detecting the effect of chloroquine (CQ) on the promotion of Wistar rat BMSCs proliferation by MT01. Methods: The third generation of Wistar rat BMSCs were cultured with different working concentrations of CQ for 24,48,72 and 96 hours, in order to detect the effect of CQ on BMSCs proliferation in dose-response relationship and aging relationship. Then, MTT assay was employed to detect the influence of CQ on MT01-stimulated BMSCs proliferation at different concentrations and different time points by adding the 1mg/L working concentration of MT01. Results: Appropriate concentration of CQ (4mg//L) could promote BMSCs proliferation. CQ exhibited the strongest promotion to BMSCs proliferation after 48 hours. Low concentrations of CQ (1mg/L and 2mg/L) inhibited the MT01-mediated promotion of BMSCs proliferation. Conclusion: CQ has an inhibitory effect on the MT01-mediated promotion of BMSCs proliferation, suggesting that MT01 may play a role by entering the endosome in BMSCs. References | Related Articles | Metrics

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Effects of Compound Skullcap Tablets on the Expression of OPG/RANKL in Human Periodontal Ligament Cells and Alveolar with Periodontitis. ZHANG Jiang-lin, WANG Hao-yu, LI Dan, YANG Xiang-di, SHI Lei, LUO Ning, CHEN Yue. 2015, 31(11): 1064-1068.  Abstract ( 176 )   PDF (1166KB) ( 363 )   Objective: To investigate effects of compound skullcap tablets on the expression of OPG/RANKL in human periodontal ligament cells (hPDLCs) and alveolar with periodontitis in SD rats. Methods: hPDLCs were isolated and identified in vitro. ELISA was used to detect the effects of compound skullcap tablets on the expression of OPG/RANKL. Rat periodontitis model was constructed by injecting LPS locally, and immunohistochemistry was used to detect effects of compound skullcap tablets on the expression of OPG/RANKL of alveolar bone in vivo. Results: Compound skullcap tablets at the concentration of 0.2μg/ml could significantly reduce the expression of RANKL in hPDLCs in vitro (P<0.05), while the expression of OPG was not significantly changed, which led to an increased ratio of OPG/RANKL (P<0.05). Immunohistochemistry showed the highest expression level of OPG in treatment group (P<0.05) and the highest expression of RANKL in periodontitis rats. Conclusion: Compound skullcap tablets can increase the ratio of OPG/RANKL and may be used to treat periodontitis clinically in the future. References | Related Articles | Metrics

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Bone Regeneration Effects of Tooth Ash in Conjunction with Platelet-rich Fibrin in an Animal Mode GUO Jin-yuan, ZHONG Wei-jian, CHAI Song-ling, LIANG Xin, MA Guo-wu. 2015, 31(11): 1069-1072.  Abstract ( 207 )   PDF (4300KB) ( 311 )   Objective: To assess the initial effects of tooth ash in conjunction with platelet-rich fibrin (PRF) on reconstruction of bone defect. Methods: Ten white rabbits were selected to create an animal model with four defects on the skull. Defects in group A was used as vacant control, tooth ash particles were used solely in group B, tooth ash mixed with PRF were used in group C, and the defects in group D were filled with tooth ash combined with bone marrow. The animals were sacrificed 6 weeks later, bone samples were harvested for histological observation and statistical analysis. Results: The percentage of new bone formed in each group was 7.46%±2.21%, 17.61%±2.29%, 21.00%±4.73%, and 23.42%±3.22%, respectively. Group C and D showed a statistically greater amount of new bone formation compared with group A and B (P<0.05). No significant differences were found between group C and D. Conclusion: Teeth ash particle is a type of bone graft material with favorable biocompatibility and osteoconductivity. After in conjunction with PRF, it can facilitate the bone healing process in early stage. References | Related Articles | Metrics

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Biocompatibility of Polylactic Acid/hydroxyapatite (PLLA/HA) Composites as Root Canal Post in Primary Anterior Teeth. GAI Li-ting, XU Gao-xiang, ZHANG Lu-lu, Gao Xiang, Jiang Qiu. 2015, 31(11): 1073-1077.  Abstract ( 270 )   PDF (2477KB) ( 241 )   Objective: To evaluate the biocompatibility of polylactic acid/hydroxyapatite(PLLA/HA) composites. Methods: According to the standard for biological evaluation of medical devices, a series of tests were performed in vivo and in vitro to evaluate the biocompatibility of PLLA/HA composites, such as cell adhesion test, hemolysis test, acute toxicity test, pyrogen test, and muscle implantation test. Results: L929 cells grew well on the PLLA/HA composites’ surface.The leaching liquor of PLLA/HAcomposites could not cause the hemolytic reaction and pyrogen reaction in rabbits and no acute toxicity in mice.The PLLA/HA composites which were implanted in rabbits’ muscle only caused a mild inflammatory reaction and a thick fiber capsule during the early stage,which subsided gradually.SEM showed that PLLA had a compact structure initially,the grains on the PLLA/HA composites were of uniform size and evenly distributed,some porous structures and cracks were observed gradually. Conclusion: The PLLA/HA composites had a good biocompatibility and met the requirement of biological safety. References | Related Articles | Metrics

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Evaluation on Corrosion Resistance of Vitallium 2000 Plus Co-Cr-Mo Alloy in SeveralDaily Drinks. CHEN Meng-nan, LI Tian-xia. 2015, 31(11): 1078-1080.  Abstract ( 163 )   PDF (1004KB) ( 310 )   Objective: To study the corrosion resistance of Vitallium 2000 plus Co-Cr-Mo alloy in several daily drinks. Methods: Artificial saliva was served as control fluid.Electrochemical technique was adopted to measure the electric potential of corrosion(Ecorr), current density of corrosion(Icorr) and polarization resistance(Rp) of Vitallium 2000 plus Co-Cr-Mo alloy in three daily drinks, i.e. milk, cola and weak alkalinity water. Microstructural and phase diffraction were examined by field scanning electron microscope(FSEM). Results: Compared with those in artificial saliva, the Icorr of Vitallium 2000 plus Co-Cr-Mo alloy in milk and weak alkalinity water groups increased whileEcorr and Rp decreased significantly.However in cola, the Icorr decreased,while Ecorr and Rp increased significantly.The corrosion resistance in all three drinks showed significant differences(P<0.05). Conclusion: The corrosion resistance of Vitallium 2000 plus Co-Cr-Mo alloy decreased significantly in milk and weak alkalinity water References | Related Articles | Metrics

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Study on Filling Depth of Z350 Composite Resin in the Access Hole of Screw Retained Implant Denture. QIN Yun, QIAN Mei, ZHU Yi-pin 2015, 31(11): 1081-1084.  Abstract ( 145 )   PDF (1624KB) ( 298 )   Objective: To speculate the influence of filling depth of Z350 composite resin on the porcelain surround the access hole of screw retained implant denture. Methods: The samples were randomly divided into three groups according to the depth of the access hole of the screw retained implant dentures, i.e. 2.0mm, 3.5mm and 5mm respectively after packing the cotton ball. The access holes were restored by Z350 composite resin. After occlusal adjustment and polishing, 10 samples were loaded with 0~100N and 1Hz force along the long axis of the implant for 20000 times. The cracks in the area around 0.5mm from the access holes were observed with field emission electron microscope. The number of the cracks in three groups was counted. Results: There was no significant difference between 3.5mm group and 5.0mm group. However, there was significant difference between 2.0mm group and 3.5mm group as well as 5.0mm group. Conclusion: The depth of 3.5mm has obvious effect on the strength of porcelain and resin. Further increase of resin depth to 5mm is not meaningful. References | Related Articles | Metrics

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Association between SNPs of MTHFR Gene and Non-syndromic Cleft Lip with or without Cleft Palate in Xinjiang Uyghur Population. KUNDEZI Du-ken, GU LI, AYIPALI Ba Wu-dong, ADILI Mo-ming. 2015, 31(11): 1085-1088.  Abstract ( 238 )   PDF (838KB) ( 276 )   Objective: To study the association between SNPs of methylenetetra hydrofolate reductase (MTHFR) gene at rs1801133,rs3818762,rs1801131,rs1476413,rs1994798 and non-syndromic cleft lip with and without cleft palate in Xinjiang Uyghur population. Methods: 100 Uyghur non-syndromic cleft lip with or without palate patients from Xinjiang were included as the study group in this study and 60 child Uyghur inpatients with upper respiratory tract infection were selected as the control group. Next generation sequencing was used to sequence the target area. Sequencing results were compared with the information in the genome database and genetic analysis was also made. Results: There were no significant differences in the frequency distribution of both genotypes and allels between cleft lip patients and controls. Analysis of the linkage disequilibrium showed that all five loci were located in the same block; rs3818762 and rs1476413 loci showed strong linkage disequilibrium (r2=0.938, D’=1). Possible haplotypes were: GCTAA>GCTAG>CTGGG>GCTGG>GCGGG. Distribution of five halotypes showed no significant differences between the study group and the control group. Conclusion: There were no significant differences in the frequency distribution of both genotypes and allels when the study group was compared with the control group at the rs1801133, rs3818762, rs1801131, rs1476413, and rs1994798 loci of MTHFR gene. References | Related Articles | Metrics

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Evaluation of FTA-DNA Direct Extraction Method in the Detection of Peri-implantitis or Periodontitis. WU Ya-ting, NIE Hong-bing, WANG Zi-jian, WANG Jia-jia, ZHOU Jian-ye, GUO Man-li. 2015, 31(11): 1089-1092.  Abstract ( 140 )   PDF (1078KB) ( 265 )   Objective: To evaluate the effect of FTA-DNA direct extraction method in the detection of peri-implantitis (PI) and periodontitis. Methods: Fourteen PI patients and 26 periodontitis patients were selected. Traditional method, boiling method, and FTA-DNA direct extraction method were used respectively to extract DNA. 16S-rDNA was amplified and gel electrophoresis was carried to compare the differences among three DNA extraction methods. Results: There was no significant difference between the peri-implantitis and periodontitis. DNA could be extracted by these three methods. FTA-DNA direct extraction significantly increased the success rate, when compared with traditional method and boiling method. Conclusion: Bacterial DNA in PI and periodontitis patients can be efficiently extracted and saved by FTA-DNA direct extraction method, which may be used to study and diagnose peri-implantitis and periodontitis. References | Related Articles | Metrics

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Electromyographic Study on Jaw-closing Muscle Induced by Preseted Levels of Clenching. ZHOU Li-juan, LI Bao-yong, WANG Mei-qing. 2015, 31(11): 1093-1095.  Abstract ( 137 )   PDF (1426KB) ( 241 )   Objective: To investigate whether force level, visual feedback and maintenance effort had synergistic effects on the electromyographic (EMG) activities of jaw-closing muscle during simulated clenching. Methods: T-Scan III and BioEMG III systems were used to evaluate the interrelationships between occlusal force and jaw-closing muscles activity of bilateral anterior temporalis (TA) and masseter (MM) muscles in 25 asymptomatic volunteers, who were enrolled to clench with low, medium, and maximum force levels, with or without visual feedback and maintenance effort. Corresponding statistics were calculated using multivariate factorial variance analysis. Results: Statistics indicated that force level and maintenance effort contributed to the increase of SEMG values in all tested jaw muscles during clenching (P<0.001) and there was an association between two factors (P<0.01). The contribution of visual feedback to the SEMG values was only noticed in TAR and MML (P>0.05). Conclusion: The SEMG activity of jaw muscles was increased when maintaining appropriate occlusal force. There was an interaction between maintaining and occlusal force. The visual feedback of occlusal force might decrease the level of SEMG activity. References | Related Articles | Metrics

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Changes of Soft Tissue Profile of Skeletal ClassⅡ High-angle Malocclusion after Tooth-extraction Treatment. JIANG Hong-tao, LIU Fan , DING Xiao-yi, YUAN Gong-jie. 2015, 31(11): 1096-1099.  Abstract ( 163 )   PDF (1438KB) ( 355 )   Objective: To evaluate the soft tissue change of skeletal Class Ⅱmalocclusion patients with vertical growth pattern after tooth extraction orthodontic treatment. Methods: 20 skeletal Class Ⅱ high-angle malocclusion patients after tooth extraction orthodontic treatment were included in this study. The pre- and post-treatment cephalometric X-rays were made and 12 measurement items were measured. The change value of pre- and post-treatment were compared. Results: TUL-EP, TLL-EP, upper and lower lip position were reduced after treatment. Nasolabial angle, Z angle, mentolabial sulcus inclination angle were enlarged. Conclusion: Soft tissue profile was improved after four premolars extraction in skeletal classⅡhigh-angle malocclusion adult patients. The relationship of sagittal jaw became coordinated after the anterior tooth retraction and the vertical height showed no significant changes. The changes of soft tissue profile were moderately correlated with changes of anterior tooth retraction and the position of both lips. References | Related Articles | Metrics

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Expression of High-mobility Group Box B1 in Human Dental Pulp Cells during OdontoblasticDifferentiation. CUI Chun, QI Sheng-cai. 2015, 31(11): 1100-1103.  Abstract ( 158 )   PDF (1779KB) ( 230 )   Objective: To investigate the expression of high-mobility group box B1 (HMGB1) in human dental pulp cells (hDPCs) during odontoblastic differentiation and explore the role of HMGB1 in dental repair. Methods: hDPCswere isolated and cultured in odontoblastic induction medium for 0, 3, 7, 11 and 14 days respectively. Important mineralization-related genes such asdental matrix protein-1 (DMP-1), dental sialophosphoprotein (DSPP) and alkaline phosphatase (ALP) were tested by real-time polymerase chain reaction. Thelevels of mRNA and protein of HMGB1 and the ALP activity were also detected. The expression pattern of HMGB1 during the hDPCsodontoblastic differentiation was detected by immunoflurescence staining. Results: The mRNA levels of DMP1 and DSPP and ALP activity were up-regulated during the hDPCsodontoblastic differentiation on days 7, 11 and 14 (P<0.05). The mRNA level of HMGB1 was significantly increased on days 11 and 14 (P<0.05). The intracellular protein level of HMGB1 was down-regulated and HMGB1 was translocated from nucleus to the cytoplasm during the procedure of odontoblastic differentiation. Conclusion: HMGB1, DMP1, DSPP/DSP and ALP showed analogously expression trend in mRNA level during the hDPCsodontoblastic differentiation. HMGB1 may play an important role in the odontogenic differentiation of hDPCs and dental repair. References | Related Articles | Metrics

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Three Dimensional Finite Element Analysis of Different Forms of Zirconia Posts on the Stress Distribution of Dentin. GUO Bin, XIE Wei-li, LIU Yi-zhi, SUN Ya-jie, CHEN Lan-zhu, LI Ya-jing, LIU Zi-chuan, AiI Zhen-long. 2015, 31(11): 1104-1107.  Abstract ( 182 )   PDF (1147KB) ( 324 )   Objective: To analyze the stress distribution of remaining dentin after restored maxillary middle incisor with different forms of zirconia posts by simulating the mechanics of body tissue with three dimensional finite element analysis. Methods: According to the standard data of adult male maxillary incisor, three-dimensional finite element models of zirconia post-and-core with parallel post, tapered post or post tapered at one end repairing for maxillary middle incisor were established and meshed using the ANSYS 11.0 software. By loading boundary conditions, the main parameters of the models were set and the static load was applied. The distribution laws of Von Mises stress in dentine were analyzed. The effect of the posts with different forms on residual dentine was evaluated. Results: The models were successfully established. The dentin stress of cylindrical post and tapered post gradually increased to the peak along the dentin boundary to the tooth neck, and the maximum dentine stress of post tapered at one end was in the apical third. The dentin stress of taper post was greater than that of cylinder post, which increased with increasing taper degree. Conclusion: The stress value of cylindrical post was lower than that of taper post. The stress value of post tapered at one end was concentrated in the apical third. Cylindrical post was the best design when choosing zirconia materials. References | Related Articles | Metrics

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Systematic Review the Influence of Acid-etching Methods on the Bonding Strength of Mild-to-moderate Dental Fluorosis Enamel. ZHANG Ling, LI Ai-ling, GAO Pan, GUO Ling. 2015, 31(11): 1108-1112.  Abstract ( 196 )   PDF (3239KB) ( 236 )   Objective:To investigate therhore effective acid-etching methods on the adhesion of mild-to-moderate dental fluorosis enamel. Methods: Randomized control trials (RCTs) or controlled clinical trials (CCTs) about enamel bonding of dental fluorosis were searched manually or by computer in 8 electronic databases without any time, region and languages limits. According to inclusion/exclusion criteria, related data were extracted, the risk of biases were evaluated, and the qualitative and quantitative analysis of the included studies were performed. Results: Eightstudies were included.The results of the Meta-analysis showed thatWMD(total-etching: mild-to-moderate dental fluorosis/normal)=-0.00,95%CI[-0.30,0.29];WMD(self-etching: mild-to-moderate dental fluorosis/normal)=-0.80,95%CI[-1.07,-0.53];WMD(mild-to-moderate dental fluorosis: self/total)=-6.08,95%CI[-7.70,-4.46]. There was no statistical difference of shear bond strength(SBS) of total-etching between mild-to-moderate dental fluorosis and normal teeth. The SBS of self-etching for mild-to-moderate dental fluorosis was lower than normal teeth.The SBS of total-etching was higher than that of self-etching. Conclusion: The SBS of total-etching shows no difference or even higher than the SBS of self-etching in enamel adhesion of mild-to-moderate dental fluorosis in the same condition. References | Related Articles | Metrics

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Effectes of Fibronectin-immobilized Microgroove Titanium Plate on Human Gingival Fibroblasts. HUANG Si-jia, XU Zhi-qiang, FAN Jian, GUO Jian-bin, ZHOU Lin, CHEN Jiang. 2015, 31(11): 1113-1117.  Abstract ( 179 )   PDF (1733KB) ( 332 )   Objective: To study the effects of fibronectin (FN)-immobilized microgroove titanium plate on human gingival fibroblasts (HGF). Methods: FN was immobilized to the microgroove of titanium plate after treated with Tresyl chloride. XPS was used to analyze the surface elements. CCK8 was used to evaluate the cell proliferation of HGFs at 6h, 12h, 1d, 3d, 5d and 7d after treated. The ELISA and real-time PCR were used to detect the secretion and expression of collagen I in HGFs at 5d. Results: All the cell number in the experimental group was higher than control group at the predetermined time (P<0.05). The stretch rate of HGFs in the experimental group was higher than control group at 3d (P<0.05). The secretion and mRNA level of collagen I in the experimental group were higher than those of control group at 5d (P<0.05). Conclusion: The FN-immobilized microgroove titanium plate could promote the proliferation, adhesion and secretion function of HGFs. References | Related Articles | Metrics

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Effect of Zirconia Crowns and Cobalt-chromium Alloy Crown Restoration on Abutment Periodontal Index and Pathogens. YAO Shi-hong, NIE Jun-jun. 2015, 31(11): 1118-1120.  Abstract ( 188 )   PDF (787KB) ( 220 )   Objective: To investigate the effect of zirconia crowns and cobalt-chromium alloy crown restoration on abutment periodontal index and pathogens. Methods: One hundred and forty-two cases of total crown restoration patients were randomly divided into Zirconia group (n=75) and Cobalt-chromium alloy group, respectively (n=67). At different time points: before restoration (T0), 6 months after restoration (T1), 12 months after restoration (T2) and 24 months after restoration (T3), the gingival color, gingival bleeding index (BI), probing depth (PD) and plaque index (PLI) were recorded. H.actinomycetemcomitans (Ha), Fusobacterium (Fn), Porphyromonas gingivalis aeromonas (Pg), Prevotella intermedia (Pi), Tannerella forsythensis (Tf) and Treponema denticola (Td) in subgingival plaque samples were detected using polymerase chain reaction (PCR) method. Results: Compared with T0, BI and PD were increased at T1~3 in both groups, BI and PD in Zirconia group were significantly less than those in Cobalt-chromium alloy group at T1~3 (P<0.05). Twelve months after restoration, the detection rates of Aa, Fn, Pg, Tf and Td in subgingival plaque samples in Zirconia group were significantly lower than those in Cobalt-chromium alloy group (P<0.05). Conclusion: Compared with cobalt-chromium alloy restoration, zirconia crown restoration is beneficial to abutment periodontal index and pathogens. References | Related Articles | Metrics

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Research on the Biomechanical Effects of Restoration Method on First Molar with Significant Loss of Coronal Structure. WANG Hui-yuan, FU Qiang, ZHANG Chun-guang, YAO Donz. 2015, 31(11): 1121-1124.  Abstract ( 143 )   PDF (1524KB) ( 342 )   Objective: To study the biomechanical effects of margin design on tooth tissue and dental prostheses on mandibular first molar with significant loss after root canal treatment (RCT). Methods: 3D finite element models of the right mandibular first molar with significant loss of coronal structure was established. After RCT, the loss was restored by endocrown,with two kinds of margin design. The models were loaded and maximum principal stress (εMax) of each part was observed. Results: Stress concentration in tooth and prostheses was different in these two kinds of restoration. Stress in enamel and prostheses were tend to be affected by margin design. Under vertical loading, peak value of enamel εMax in butt-joint margin group was 42.88% lower than that of the 90° margin group, with stress concentrating on dentino-enamel junction and enamel surface near margin area. Under vertical loading, peak value of ceramic εMax in butt-joint margin group was 45.55% lower than that of the 90° margin group, with stress concentrating on retention cavity inside the pulp chamber and tooth surface near margin area. Under lingual-buccal loading, peak value of ceramic εMax in butt-joint margin group was 12.58% lower than that of the 90° margin group, with stress concentrating on the bottom of the pulp chamber and tooth surface near margin area. Conclusion: Endocrown with butt-joint margin design was helpful to protect enamel and improve stress distribution of the prostheses. And from the view of biomechanics, it was positive to insure long-term stability. References | Related Articles | Metrics

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Association Between Tooth Loss and Esophageal Cancer: A Meta-analysis of Case-control Studies. YANG Sheng-jun, LEI Zhi-min. 2015, 31(11): 1125-1128.  Abstract ( 157 )   PDF (1301KB) ( 182 )   Objective: To evaluate the association between tooth loss and esophageal cancer (EC). Methods: We conducted electronic searches of PubMed and CNKI until January 10, 2015 to identify relevant case-control studies on the association between tooth loss and the risk of EC. Study selection and data extraction from eligible studies were independently performed by 2 investigators. The meta-analysis was conducted using RevMan 5.3 software. Publication bias was also investigated. Results: Four eligible publications with 5 case-control studies were included. The results of meta-analysis identified that tooth loss increased the risk of EC by 1.44 times (Odds ratio: 1.44, 95% confidence interval: 1.23-1.68, P<0.001). Subgroup analysis proved similar results and publication bias was not detected. Conclusion: Based on the current evidences, tooth loss could be considered as a significant and dependent risk factor for EC. Therefore, the population with tooth loss should be vigilant for symptoms of EC. References | Related Articles | Metrics

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Prospective Clinical Research of A New Bone Substitutes in Repairing Alveolar Bone Defects. CHEN Dong, BAI Yi, LI Rong, ZHANG Yu-feng, XIA Hai-bin, SHI Bin, TONG Xin, DENG Chun-fu, YIN Li-qiang. 2015, 31(11): 1129-1132.  Abstract ( 189 )   PDF (983KB) ( 615 )   Objective: To compare the restoration effect of a new deproteinized mineral bovine bone and Bio-oss bone in the bone defect around dental implant. Methods: The prospective clinical trial design was blinded, random, open, and parallel control. 180 patients were divided into two groups randomly. In the experimental group, 90 patientswere treated with a new deproteinized mineral bovine bone and Bio-gide. In the control group, 90 patients were treated with Bio-oss bone dust and Bio-gide. The patients were checked by CT at pre-operation, the day of surgery, and 6 months after surgery. The effective bone turnover rate was counted asthe ratio of cases equalorgreaterthan 80% of bone turnover rate to the total cases.It was used as the criteriato evaluate the effect of bone substitutes. Results: At postoperative 6 months, the bone conversion efficiency rate of test group was 85.39%, which was higher than that of control group (82.95%, P=0.0117). However, on the time of surgery, there was no significant difference between the experimental and control groups. Conclusion: New deproteinized mineral bovine bone and Bio-oss bone dust have the same clinical effect on repairing alveolar bone defect around dental implant. Both of them have no side effect. References | Related Articles | Metrics

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Clinical Study of Multi-point Radiofrequency Ablation in Treatment of Trigeminal Neuralgia. DENG Li, ZHANG Qing-Bin, ZHANG Ying, HE Xia. 2015, 31(11): 1133-1135.  Abstract ( 158 )   PDF (1121KB) ( 156 )   Objective: To investigate the clinical efficacy of multi-point radiofrequency ablation in the treatment of trigeminal neuralgia. Methods: 64 patients who suffered from trigeminal neuralgia were included in this study. They were randomly divided into two groups, 32 patients in the treatment group and 32 patients in the control group. Patients in the treatment group were treated with multi-point radiofrequency ablation while those in the control group were treated by nerve blocking. The efficacy in two groups was compared after treatment. Results:The VAS scores in the treatment group were lower than those in the control group. One day after multi-point radiofrequency ablation, the VAS score in the treatment group decreased from 8.52±2.25 to 2.21±2.05. The effective rate was 96.9%. While the VAS score in the control group decreased from 8.48±2.16 to 4.23±2.12 and the effective rate was 65.6%. There were significant differences between two groups (P<0.05). Conclusion:The multi-point radiofrequency ablation is more effective in the treatment of trigeminal neuralgia, meanwhile with fewer complications and higher security. References | Related Articles | Metrics

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Effects of Traction Position on the Periodontal Stress Distribution of Impacted Maxillary Central Incisor. HAO Yan, HUI Ji-fang, ZHENG Wen-tao, Shao Ping 2015, 31(11): 1136-1139.  Abstract ( 184 )   PDF (1769KB) ( 178 )   Objective: To analyze the stress of periodontal tissues in different conditions by establishing the three dimensional finite element model of an impacted labial inverted maxillary central incisor and its supporting tissues,and to provide some reference for the treatment of impacted maxillary central incisor. Methods: Three-dimensional finite element model of impacted labial inverted maxillary central incisor and its periodontal tissues were established based on original data of cone beam computed tomography (CBCT). Various tractions (30g, 60g, 90g) were exerted on the incisal, middle and cervical of the lingual surface in the direction perpendicular to the impacted incisor, respectively. And then, different Von Mises stress was determined and analyzed. Results: The characteristics of stress distribution were similar in different traction position. The closer the traction to the cervix was, the smaller stress distribution in periodontal ligament was. The bigger the traction power was, the larger stress distribution in periodontal ligament was. Conclusion:The traction position had better be exerted on the incisal margin and the optimal traction power should not exceed 60g. References | Related Articles | Metrics

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Effects of Two Pathways of Lingual Plates in Extraction of Low Impacted Mandibular Third Molars on Postoperative Tissue Reaction. YANG Zhi-feng. 2015, 31(11): 1140-1139.  Abstract ( 140 )   PDF (946KB) ( 238 )   Objective: To investigate the effects of two pathways of lingual plates in the extraction of low impacted mandibular third molars on postoperative tissue reaction. Methods: 136 patients undergoing low impacted mandibular third molar were randomly divided into bone plate resection group (n=67) and bone plate splitting surgery group (n=69). Lingual plate resection and lingual plate splitting surgery were performed for teeth extraction, respectively. The operating time, postoperative pain and facial swelling occurrence of the two groups were recorded. At 48h and 7d after surgery, the degrees of mouth opening and odynophagia of the two groups were compared. Results: After surgery, all patients reached healing. The operation time in bone plate splitting surgery group was shorter than the bone plate resection group, and facial swelling was less than the bone plate resection group (P<0.05). At 48h and 7d after surgery, the degrees of mouth opening in the two groups were reduced (P<0.05). At 48h after surgery, the degree of mouth opening in bone plate splitting surgery group was greater than the bone plate resection group, and meanwhile the occurrence of odynophagia was less (P<0.05). At 7d after surgery, the differences in the degree of mouth opening and odynophagia between the two groups were not significant. Conclusion: Compared with lingual plate resection, lingual plate splitting surgery used in the extraction of low impacted mandibular third molars could effectively reduce the operation time and the occurrence of facial swelling, accompanied by less postoperative tissue reaction. References | Related Articles | Metrics

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Effect of Occlusion Relationship on Electromyography Activities of Masticatory Muscle. HE Yuan, ZHANG Qi, LI Tian-shu, FU Gui-yuan, XU Lin, YI Long, WANG Jia-ying, GUZAILI, GAO Lu. 2015, 31(11): 1143-1147.  Abstract ( 143 )   PDF (1341KB) ( 312 )   Objective: To measure the electromyograph (EMG) activities of masticatory muscles in different occlusal patterns by electromyography. Methods: Thirty-three volunteers from Dalian Medical University were divided into four groups: normal control group (n=10), Angle's classⅠmalocclusion group (n=10), Angle's class Ⅱ malocclusion group (n=8) and Angle's class Ⅲ malocclusion group (n=5). Electromyograph was used to measure the EMG activities of masticatory muscles in different occlusal patterns and the data were analyzed by SPSS. Results: In rest position, EMG activities had no significant difference among the four groups. However, during jaw clenching, EMG activity in the masseter of Angle's class Ⅲ malocclusion group was significantly different from those of other three groups. In swallow condition, both EMG activities in the masseter of Angle's class Ⅱ and Ⅲ malocclusion groups were different from that of normal control group. EMG activity in the digastric muscle of Angle's class Ⅲ group was also different from those of other three groups. There were both correlation and differences in the EMG activities of two sides of the masticatory muscles between different occlusal patterns. Conclusion: EMG activities of masticatory muscles between different occlusal patterns were different. Malocclusion may influence the normal function of masticatory muscles. References | Related Articles | Metrics

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Expression and Distribution of CCL28 in Labial Glands of Sjgren Disease LIU Xue, LIU Zhong-hao, LU Zhi-shan, GAO Yue-hua. 2015, 31(11): 1148-1150.  Abstract ( 161 )   PDF (1109KB) ( 231 )   Objective: To detect the expression and distribution of CCL28 in human labial glands of Sjogren disease. Methods: All labial gland samples came from 35 patients who were diagnosed as Sjogren disease. CCL28 mRNA was detected by semiquantitative RT-PCR and CCL28 protein was detected by immunohistochemistry. Results: CCL28 mRNA was expressed in the labial glands of Sjogren disease, which was lower than that in the control. Positive staining of CCL28 was identified in the glandular epithelial cells, duct epithelial cells and mucus. Conclusion: CCL28 expressed and distributed in the labial glands of Sjogren disease. This would help doctors prevent tooth decay and oral infections in these patients. References | Related Articles | Metrics

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Study on Metabolism and Morphological Symmetry of Bilateral TMJ of Adult Patients with Mandibular Deviation using SPECT-CT. SHI Cong-chong, LIU Chao, ZHANG Xiao-rong, DENG Zhi-yong, LI Song. 2015, 31(11): 1151-1153.  Abstract ( 142 )   PDF (1112KB) ( 353 )   Objective: To study metabolism and morphological symmetry of bilateral TMJ of adult patients with mandibular deviation by utilizing SPECT-CT. Methods: Thirty-six adult patients with mandibular deviation were conducted SPECT. The images of condyle process, mandibular ramus and angle of mandible were gathered and rebuilt from coronal, sagittal and cross section planes. Then, the radioactive count ratios were calculated and acquired fusion images after CT scanning and three-dimensional reconstruction. The condyle process height, internal and external diameters, back bevel slant angle and back bevel length were measured and compared according to bilateral TMJ's anatomic relation. Results: The radioactive counting ratios in different areas (condyle process, mandibular ramus, angle of mandible) were different, the radioactive counting ratios in the lateral side were lower than those of the opposite side, and the radioactive counting ratios of both sides showed statistical difference (P＜0.05). The condyle process height, internal and external diameters in the lateral side were smaller than those in the lateral side (P<0.01); Back bevel slant angle and length in the lateral side were larger than those in the opposite side (P<0.01). Conclusion: SPECT-CT bone imaging plays a crucial role in diagnosing and assessing mandibular deviation of adult patients. References | Related Articles | Metrics

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Research Progress in the Osseoperception Phenomena of Dental Implant. MENG Xing, ZHAO Jing-hui, ZHOU Yan-min, MA Shan-shan, ZHANG Hong-yi 2015, 31(11): 1156-1158.  Abstract ( 196 )   PDF (797KB) ( 335 )   The potential mechanism of osseoperception of dental implant, a widely observed phenomenon, is still not clear. In recent years, many methods, including neurophysiology, psychophysics, and functional magnetic resonance imaging, were tried to reveal the underlying mechanism. This article reviews the research progress in the osseoperception phenomena of dental implant. References | Related Articles | Metrics

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Application of Electrospinning Technique in Periodontal Tissue Engineering. XU Yan, BAO Chong-yun. 2015, 31(11): 1159-1153.  Abstract ( 282 )   PDF (847KB) ( 546 )   Electrospinning technique could prepare many nanofiber scaffolds with various characteristics through electrostatic principles. These nanofibers contained many advantages including high superficial area, high porosity, and the ability to simulate structures of extracellular matrix to a large extent. This article introduced the preparation process and the biological nature of electrospinning technique as well as the application of nanofibers in the periodontal tissue engineering, guided tissue regeneration, and periodontal drug sustained release system. Furthermore, the development of this technique in the future was expected References | Related Articles | Metrics

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Effect of Sintering on the Properties of Dental Zirconia Ceramics. ZHAN Wen-hui, JIANG Yue-mei, HUANG Wei. 2015, 31(11): 1164-1168.  Abstract ( 272 )   PDF (793KB) ( 677 )   Zirconia ceramics are widely used due to their superior biomedical, aesthetic and mechanical properties. The properties of zirconia ceramics have a close relationship with their chemical composition and microstructure. Among these factors, the sintering has a major impact on the microstructure of zirconia ceramics. The purpose of this paper is to review the effect of sintering on the properties of dental zirconia ceramics. References | Related Articles | Metrics