Abstract: Objective: To evaluate the soft tissue change of skeletal Class Ⅱmalocclusion patients with vertical growth pattern after tooth extraction orthodontic treatment. Methods: 20 skeletal Class Ⅱ high-angle malocclusion patients after tooth extraction orthodontic treatment were included in this study. The pre- and post-treatment cephalometric X-rays were made and 12 measurement items were measured. The change value of pre- and post-treatment were compared. Results: TUL-EP, TLL-EP, upper and lower lip position were reduced after treatment. Nasolabial angle, Z angle, mentolabial sulcus inclination angle were enlarged. Conclusion: Soft tissue profile was improved after four premolars extraction in skeletal classⅡhigh-angle malocclusion adult patients. The relationship of sagittal jaw became coordinated after the anterior tooth retraction and the vertical height showed no significant changes. The changes of soft tissue profile were moderately correlated with changes of anterior tooth retraction and the position of both lips.