Abstract: Objective: To study the corrosion resistance of Vitallium 2000 plus Co-Cr-Mo alloy in several daily drinks. Methods: Artificial saliva was served as control fluid.Electrochemical technique was adopted to measure the electric potential of corrosion(Ecorr), current density of corrosion(Icorr) and polarization resistance(Rp) of Vitallium 2000 plus Co-Cr-Mo alloy in three daily drinks, i.e. milk, cola and weak alkalinity water. Microstructural and phase diffraction were examined by field scanning electron microscope(FSEM). Results: Compared with those in artificial saliva, the Icorr of Vitallium 2000 plus Co-Cr-Mo alloy in milk and weak alkalinity water groups increased whileEcorr and Rp decreased significantly.However in cola, the Icorr decreased,while Ecorr and Rp increased significantly.The corrosion resistance in all three drinks showed significant differences(P<0.05). Conclusion: The corrosion resistance of Vitallium 2000 plus Co-Cr-Mo alloy decreased significantly in milk and weak alkalinity water