Biocompatibility of Polylactic Acid/hydroxyapatite (PLLA/HA) Composites as Root Canal Post in Primary Anterior Teeth.

Abstract

Abstract: Objective: To evaluate the biocompatibility of polylactic acid/hydroxyapatite(PLLA/HA) composites. Methods: According to the standard for biological evaluation of medical devices, a series of tests were performed in vivo and in vitro to evaluate the biocompatibility of PLLA/HA composites, such as cell adhesion test, hemolysis test, acute toxicity test, pyrogen test, and muscle implantation test. Results: L929 cells grew well on the PLLA/HA composites’ surface.The leaching liquor of PLLA/HAcomposites could not cause the hemolytic reaction and pyrogen reaction in rabbits and no acute toxicity in mice.The PLLA/HA composites which were implanted in rabbits’ muscle only caused a mild inflammatory reaction and a thick fiber capsule during the early stage,which subsided gradually.SEM showed that PLLA had a compact structure initially,the grains on the PLLA/HA composites were of uniform size and evenly distributed,some porous structures and cracks were observed gradually. Conclusion: The PLLA/HA composites had a good biocompatibility and met the requirement of biological safety.

CLC Number:

R788

GAI Li-ting, XU Gao-xiang, ZHANG Lu-lu, Gao Xiang, Jiang Qiu.. Biocompatibility of Polylactic Acid/hydroxyapatite (PLLA/HA) Composites as Root Canal Post in Primary Anterior Teeth.[J]. Journal of Oral Science Research, 2015, 31(11): 1073-1077.

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