Journal of Oral Science Research ›› 2015, Vol. 31 ›› Issue (11): 1125-1128.

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Association Between Tooth Loss and Esophageal Cancer: A Meta-analysis of Case-control Studies.

YANG Sheng-jun, LEI Zhi-min.   

  1. People's Hospital of Wuhan University, Wuhan 430000, China
  • Received:2015-04-23 Online:2015-11-28 Published:2016-03-21

Abstract: Objective: To evaluate the association between tooth loss and esophageal cancer (EC). Methods: We conducted electronic searches of PubMed and CNKI until January 10, 2015 to identify relevant case-control studies on the association between tooth loss and the risk of EC. Study selection and data extraction from eligible studies were independently performed by 2 investigators. The meta-analysis was conducted using RevMan 5.3 software. Publication bias was also investigated. Results: Four eligible publications with 5 case-control studies were included. The results of meta-analysis identified that tooth loss increased the risk of EC by 1.44 times (Odds ratio: 1.44, 95% confidence interval: 1.23-1.68, P<0.001). Subgroup analysis proved similar results and publication bias was not detected. Conclusion: Based on the current evidences, tooth loss could be considered as a significant and dependent risk factor for EC. Therefore, the population with tooth loss should be vigilant for symptoms of EC.

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