In Vitro Study on Promotion of Enamel Re-mineralization by Tin (Ⅱ) Fluoride (SnF2) Combined with Ferumoxytol

doi:10.13701/j.cnki.kqyxyj.2026.02.007

Abstract

Abstract: Objective: To investigate the role of SnF₂ in combination with ferumoxytol in promoting the remineralization of demineralized enamel of isolated teeth. Methods: Eighty enamel slices that met the standards were prepared and immersed in demineralization solution to simulate the demineralization process of dental tissues in the human oral cavity. After demineralization, they were divided into experimental and control groups. The experimental group was further divided into sodium fluoride (NaF) group, SnF₂ group, and different concentrations of SnF₂ combined with ferumoxytol group. The control group was immersed in deionized water. After the immersion, their microhardness was measured respectively, and scanning electron microscopy observation and mass spectrometry analysis were carried out. Results: The remineralization effect of the 100 PPM SnF₂ combined with ferumoxytol solution group was basically the same as that of the 250 PPM SnF₂ solution group. Conclusion: 100 PPM SnF₂ combined with ferumoxytol solution effectively reduces the usage concentration of fluorine preparations and makes the aqueous solution of SnF₂ fluoride stable.

Key words: demineralization, remineralization, sodium fluoride, tin (Ⅱ) fluoride, ferumoxytol

LI Jielong, HUO Fengli, QI Fangfang, ZHAO Zihan, DONG Haoran, CHEN Ruixue. In Vitro Study on Promotion of Enamel Re-mineralization by Tin (Ⅱ) Fluoride (SnF₂) Combined with Ferumoxytol[J]. Journal of Oral Science Research, 2026, 42(2): 121-125.

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In Vitro Study on Promotion of Enamel Re-mineralization by Tin (Ⅱ) Fluoride (SnF₂) Combined with Ferumoxytol

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