Comparison of Leptin Levels in Gingival Crevicular Fluid of Different Periodontal Status

Abstract

Abstract: Objective: To evaluate gingival crevicular fluid (GCF) leptin levels and their relationship with periodontal health and disease. Methods: Forty-two individuals were divided into three groups: healthy subjects, patients with chronic gingivitis and chronic periodontitis. For each subject, plaque index (PLI), pocket depth (PD), bleeding index (BI), and attachment level (AL) values were recorded before and after treatment. GCF samples (by Whatman^ 1 filter paper) and serum samples (by venipuncture) were respectively collected to determine the leptin levels using enzyme-linked immunosorbent assay (ELISA) kit. Results: The lowest GCF leptin level was observed in subjects with chronic periodontitis, and statistically significant compared with healthy subjects (P<0.05). In contrast, the highest serum leptin concentration was obtained for subjects with chronic periodontitis. The PLI, PD, BI, and AL all showed significant correlations with leptin levels in GCF and serum (P<0.05). Conclusion: Leptin levels in GCF may be used as an objective indicator to evaluate periodontal status.

Key words: Periodontitis, Gingivitis, Gingival crevicular fluid, Leptin

CLC Number:

R781.4

LIU Chong-wu, WU Chun-fang, LUO Kai, et al. Comparison of Leptin Levels in Gingival Crevicular Fluid of Different Periodontal Status[J]. Journal of Oral Science Research, 2015, 31(8): 798-.

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