Abstract: Objective: To investigate the effect of strontium ranelate on osseointergration in osteoporotic rats. Method: Thirty-six female rats were randomly divided into three groups: ovariectomization group(A=12), strontium ranelate lower dose treatment group(B=12) and strontium ranelate high dose treatment group(C=12). Animals all received bilateral ovariectomy. After the success of the osteoporosis model building, HA coated titanium implants were inserted into proximal metaphyses of tibiae, meanwhile, the animals of group B and C were received oral medication strontium ranelate(B:450mg·kg^-1·d^-1 C:900mg·kg^-1·d^-1), Twelve weeks after surgery, animals were killed and undecalcified sections were prepared and examined histologically, micro-CT examnation and histomorphometrically. Results: 12 weeks after implantation surgery, BMD, IBCR and NBV in group B and C were significantly higher then those in group A(P<0.01). Conclusion: Strontium ranelate may resist the negative influence of osteoporosis and promote osseointagration of implant.

Key words: Dental implants, Osteoporosis, Osseointegration