Abstract: Cleft lip and/or palate (CL/P) is the most common orofacial malformation. Half of cases are Cleft lip and palate. CL/P may occur as an isolated finding or may be found in association with other congenital malformations. Major medical and psychological problems may ensue following this diagnosis for both the child and its family. It is important that they are diagnosed as early as possible during the antenatal period to allow adequate counseling of the parents and to provide neonatal care. Prenatal ultrasonographic screening is found to be an accurate tool for the prenatal diagnosis of CL/P in high risk groups, particularly when it is associated with other structural malformations. Magnetic resonance imaging may be ancillary to ultrasound in prenatal investigation of a fetus with cleft lip, allowing a better staging of the lesion by demonstrating the degree of involvement of the palate. Prenatal genetic examination can determine whether the fetus associated with CL/P cause chromosomal disease research.

Key words: Cleft, lip, and, palate, Postnasal, diagnosis, Ultrasound