微小RNA在口腔白斑病诊断及治疗中的应用

doi:10.13701/j.cnki.kqyxyj.2022.09.002

口腔医学研究 ›› 2022, Vol. 38 ›› Issue (9): 807-810.DOI: 10.13701/j.cnki.kqyxyj.2022.09.002

微小RNA在口腔白斑病诊断及治疗中的应用

刘佳鑫, 但红霞^*

口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,口腔黏膜病国家临床重点专科,中国医学科学院口腔黏膜癌变与防治创新单元,四川大学华西口腔医院四川成都 610041

收稿日期:2021-07-19 发布日期:2022-09-26
通讯作者: 但红霞,E-mail:hxdan@foxmail.com
作者简介:刘佳鑫(1997~ ),男,四川自贡人,硕士在读,研究方向:口腔黏膜病的发病机制和防治。
基金资助:
国家自然科学基金(编号:82071125,U19A2005)四川省科技计划项目(编号:2020YFS0044,2020YFSY009)四川大学华西口腔医院探索与研发项目(编号:LCYJ2019-11)

pplication of MicroRNAs in Diagnosis and Treatment of Oral Leukoplakia

LIU Jiaxin, DAN Hongxia^*

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Received:2021-07-19 Published:2022-09-26

摘要/Abstract

摘要： 微小RNA是一种内源性、高度保守的非编码RNA,参与机体多种生物活动,并且和多种癌症的发生和发展密切相关。近期的研究发现微小RNA具有作为口腔白斑病癌变风险预测的分子标记物和治疗靶点的潜力。本文就微小RNA在口腔白斑病临床应用的研究进展做一综述。

关键词: 微小RNA, 口腔白斑病, 恶性转化

Abstract: MicroRNA (miRNA) is an endogenous highly conserved non-coding RNA, which is involved in various biological activities of the body, and is closely related to the development of a variety of cancers. Recent studies have shown the potential of miRNAs as a molecular marker for malignant transformation of oral leukoplakia and therapeutic target of oral leukoplakia. In this study, the application of miRNAs in the diagnosis and treatment of oral leukoplakia was reviewed.

Key words: microRNA, oral leukoplakia, malignant transformation

刘佳鑫, 但红霞. 微小RNA在口腔白斑病诊断及治疗中的应用[J]. 口腔医学研究, 2022, 38(9): 807-810.

LIU Jiaxin, DAN Hongxia. pplication of MicroRNAs in Diagnosis and Treatment of Oral Leukoplakia[J]. Journal of Oral Science Research, 2022, 38(9): 807-810.

参考文献

[1] Mello FW, Miguel AFP, Dutra KL, et al. Prevalence of oral potentially malignant disorders: A systematic review and meta-analysis [J]. J Oral Pathol Med, 2018, 47(7):633-640.
[2] Pinto AC, Caramês J, Francisco H, et al. Malignant transformation rate of oral leukoplakia-systematic review [J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2020, 129(6):600-611.
[3] 杨凯成,杨蕾,赵建广,等. 口腔鳞状细胞癌患者外周血microRNA的表达及预后意义[J]. 口腔医学研究,2020, 36(5):428-432.
[4] Ghafouri-Fard S, Shoorei H, Anamag FT, et al. The role of non-coding RNAs in controlling cell cycle related proteins in cancer cells [J]. Front Oncol, 2020, 10:608975.
[5] Niu T, Zhang W, Xiao W. MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer [J]. Cancer Cell Int, 2021, 21(1):31.
[6] Torsin LI, Petrescu GED, Sabo AA, et al. Editing and chemical modifications on non-coding RNAs in cancer: A new tale with clinical significance [J]. Int J Mol Sci, 2021, 22(2):581.
[7] Volovat SR, Volovat C, Hordila I, et al. MiRNA and lncRNA as potential biomarkers in triple-negative breast cancer: A review [J]. Front Oncol, 2020, 10:526850.
[8] Iqbal MA, Arora S, Prakasam G, et al. MicroRNA in lung cancer: role, mechanisms, pathways and therapeutic relevance [J]. Mol Aspects Med, 2019, 70:3-20.
[9] Carthew RW, Sontheimer EJ. Origins and mechanisms of miRNAs and siRNAs [J]. Cell, 2009, 136(4):642-655.
[10] Ruby JG, Jan CH, Bartel DP. Intronic microRNA precursors that bypass Drosha processing [J]. Nature, 2007, 448(7149):83-86.
[11] Chen D, Cabay RJ, Jin Y, et al. MicroRNA deregulations in head and neck squamous cell carcinomas [J]. J Oral Maxillofac Res, 2013, 4(1):e2.
[12] Saliminejad K, Khorram Khorshid HR, Soleymani Fard S, et al. An overview of microRNAs: Biology, functions, therapeutics, and analysis methods [J]. J Cell Physiol, 2019, 234(5):5451-5465.
[13] Bayraktar R, Van Roosbroeck K, Calin GA. Cell-to-cell communication: microRNAs as hormones [J]. Mol Oncol, 2017, 11(12):1673-1686.
[14] Ouyang T, Liu Z, Han Z, et al. MicroRNA detection specificity: Recent advances and future perspective [J]. Anal Chem, 2019, 91(5):3179-3186.
[15] Cheng Y, Dong L, Zhang J, et al. Recent advances in microRNA detection [J]. Analyst, 2018, 143(8):1758-1774.
[16] Tian T, Wang J, Zhou X. A review: microRNA detection methods [J]. Org Biomol Chem, 2015, 13(8):2226-2238.
[17] Villa A, Sonis S. Oral leukoplakia remains a challenging condition [J]. Oral Dis, 2018, 24(1-2):179-183.
[18] Monteiro L, Mello FW, Warnakulasuriya S. Tissue biomarkers for predicting the risk of oral cancer in patients diagnosed with oral leukoplakia: A systematic review[J]. Oral Dis, 2021, 27(8):1977-1992.
[19] Liu CJ, Tsai MM, Hung PS, et al. miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma[J]. Cancer Res, 2010, 70(4):1635-1644.
[20] Liu CJ, Lin SC, Yang CC, et al. Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma [J]. Head Neck, 2012, 34(2): 219-224.
[21] Liu C, Kao S, Tu H, et al. Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer [J]. Oral Dis, 2010, 16(4):360-364.
[22] Chang KW, Kao SY, Wu YH, et al. Passenger strand miRNA miR-31^* regulates the phenotypes of oral cancer cells by targeting RhoA [J]. Oral Oncol, 2013, 49(1):27-33.
[23] Xiao W, Bao ZX, Zhang CY, et al. Upregulation of miR-31^* is negatively associated with recurrent/newly formed oral leukoplakia [J]. PLoS One, 2012, 7(6):e38648.
[24] Maimaiti A, Abudoukeremu K, Tie L, et al. MicroRNA expression profiling and functional annotation analysis of their targets associated with the malignant transformation of oral leukoplakia [J]. Gene, 2015, 558(2):271-277.
[25] Roy R, Singh R, Chattopadhyay E, et al. MicroRNA and target gene expression based clustering of oral cancer, precancer and normal tissues [J]. Gene, 2016,593(1):58-63.
[26] Chen H, Liu X, Jin Z, et al. A three miRNAs signature for predicting the transformation of oral leukoplakia to oral squamous cell carcinoma [J]. Am J Cancer Res, 2018, 8(8):1403-1413.
[27] Philipone E, Yoon AJ, Wang S, et al. MicroRNAs-208b-3p, 204-5p, 129-2-3p and 3065-5p as predictive markers of oral leukoplakia that progress to cancer [J]. Am J Cancer Res, 2016, 6(7):1537-1546.
[28] Cervigne NK, Reis PP, Machado J, et al. Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma [J]. Hum Mol Genet, 2009, 18(24):4818-4829.
[29] Brito JAR, Gomes CC, Guimares ALS, et al. Relationship between microRNA expression levels and histopathological features of dysplasia in oral leukoplakia [J]. J Oral Pathol Med, 2014, 43(3):211-216.
[30] Ranganathan K, Kavitha L. Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders [J]. J Oral Maxillofac Pathol, 2019, 23(1):19-27.
[31] Holmstrup P, Vedtofte P, Reibel J, et al. Oral premalignant lesions: is a biopsy reliable? [J]. J Oral Pathol Med, 2007, 36(5):262-266.
[32] Li W, Han Y, Zhao Z, et al. Oral mucosal mesenchymal stem cellderived exosomes: A potential therapeutic target in oral premalignant lesions [J]. Int J Oncol, 2019, 54(5):1567-1578.
[33] Wang L, Yin P, Wang J, et al. Delivery of mesenchymal stem cells-derived extracellular vesicles with enriched miR-185 inhibits progression of OPMD [J]. Artif Cells Nanomed Biotechnol, 2019, 47(1):2481-2491.

微小RNA在口腔白斑病诊断及治疗中的应用

pplication of MicroRNAs in Diagnosis and Treatment of Oral Leukoplakia

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