CGF辅助治疗MillerⅠ类牙龈退缩的临床评价

doi:10.13701/j.cnki.kqyxyj.2023.12.008

口腔医学研究 ›› 2023, Vol. 39 ›› Issue (12): 1069-1074.DOI: 10.13701/j.cnki.kqyxyj.2023.12.008

CGF辅助治疗MillerⅠ类牙龈退缩的临床评价

蔡松梅^1,2, 汪涌^1,2,3*

1.安徽医科大学合肥口腔临床学院安徽合肥 230061;
2.安徽医科大学第五临床医学院安徽合肥 230032;
3.合肥市口腔医院牙周黏膜科安徽合肥 230001

收稿日期:2023-07-14 出版日期:2023-12-28 发布日期:2023-12-25
通讯作者: * 汪涌,E-mail:yllwywzy@126.com
作者简介:蔡松梅(1997~ ),女,安徽宣城人,硕士在读,医师,主要研究方向为牙周病学。
基金资助:
2023年合肥市口腔医院院级重点科研项目(院科教[2023]26号)合肥市第六周期医学重点专科建设项目(合卫科教[2019]160号)

Clinical Evaluation of CGF Assisted Treatment of Miller Class Ⅰ Gingival Recession

CAI Songmei^1,2, WANG Yong^1,2,3*

1. Hefei College of Stomatology, Anhui Medical University, Hefei 230061, China;
2. The Fifth Clinical Medical School, Anhui Medical University, Hefei 230032, China;
3. Department of Periodontics and Disease of Oral Mucosa, Hefei Stomatological Hospital, Hefei 230001, China

Received:2023-07-14 Online:2023-12-28 Published:2023-12-25

摘要/Abstract

摘要： 目的:评估浓缩生长因子(concentrate growth factors,CGF)作为辅助性材料联合冠向复位瓣(coronally advanced flap,CAF)与结缔组织移植(connective tissue graft,CTG),治疗MillerⅠ类牙龈退缩(gingival recession,GR)的临床疗效。方法:将30例MillerⅠ类GR患者(共计42个GR位点)视为本研究试验对象,随机分为试验组(CAF+CTG+CGF)和对照组(CAF+CTG),每组15例,比较两组患者的术后效应。结果:术后6个月,比较试验组和对照组牙龈退缩高度和宽度的减少、角化龈宽度的增加及术后24 h、2 d及7 d的数字评价量表(用以评估术后疼痛肿胀情况)评分,差异均有统计学意义(P＜0.05)。完全根面覆盖率,试验组(90.90%)和对照组(65.00%)比较差异无统计学意义(P＞0.05)。结论:CGF作为CAF+CTG的辅助性材料运用于Miller Ⅰ类GR中,可以减少术后6个月的牙龈退缩高度及宽度,增加角化龈宽度,改善术后24 h、2 d及7 d的疼痛肿胀情况,为GR治疗开拓了新思路。

关键词: 牙龈退缩, 浓缩生长因子, 结缔组织移植物, 冠向复位瓣

Abstract: Objective: To estimate the effectiveness of concentrate growth factors (CGF) combined with connective tissue graft (CTG) and coronally advanced flap (CAF) for the treatment of Miller Class Ⅰ gingival recession (GR). Methods: Thirty GR patients with Miller Class Ⅰ (42 sites) were selected and randomly divided into experimental group (CAF+CTG+CGF) and control group (CAF+CTG), with 15 cases in each group. The postoperative effects of the two groups were compared. Results: Six months after operation, the decrease of gingival recession height and width, the increase of keratinized tissue width, and the score of numerical rating scale (used to estimate postoperative pain and swelling) at 24 h, 2 d, and 7 d after surgery were statistically significant (P<0.05). However, there was no significant difference in the complete root coverage between experimental group (90.90%) and control group (65.00%, P>0.05). Conclusion: CGF, as an auxiliary material for CAF+CTG, can reduce the height and width of gingival recession 6 months after surgery, increase the keratinized tissue width, and ameliorate the pain and swelling at 24 h, 2 d, and 7 d after surgery, which opens up a new idea for the treatment of GR.

Key words: gingival recession, concentrate growth factors, connective tissue graft, coronally advanced flap

蔡松梅, 汪涌. CGF辅助治疗MillerⅠ类牙龈退缩的临床评价[J]. 口腔医学研究, 2023, 39(12): 1069-1074.

CAI Songmei, WANG Yong. Clinical Evaluation of CGF Assisted Treatment of Miller Class Ⅰ Gingival Recession[J]. Journal of Oral Science Research, 2023, 39(12): 1069-1074.

参考文献

[1] Jepsen S, Caton JG, Albandar JM, et al. Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions [J]. J Clin Periodontol, 2018, 45 Suppl 20: S219-S229.
[2] Imber J, Kasaj A. Treatment of gingival recession: When and how? [J]. Int Dent J, 2021,71(3):178-187.
[3] Keceli HG, Kamak G, Erdemir EO, et al. The adjunctive effect of platelet-rich fibrin to connective tissue graft in the treatment of buccal recession defects: Results of a randomized, parallel-group controlled trial [J]. J Periodontol, 2015, 86(11): 1221-1230.
[4] 陆英,王似鋆,邹多宏.浓缩生长因子在口腔组织再生工程中的应用研究新进展[J].中国医学科学院学报,2023,45(3):500-505.
[5] 应绚,陈悦,张凯利.改良隧道技术治疗牙龈退缩合并非龋性牙颈部缺损的临床研究[J].华西口腔医学杂志,2019,37(5):496-500.
[6] 周颐,刘笑言,向柄彦.组织修复和再生领域浓缩生长因子的应用优势[J].中国组织工程研究,2022,26(10):1631-1640.
[7] Moraschini V, Barboza Edos S. Use of platelet-rich fibrin membrane in the treatment of gingival recession: A systematic review and meta-analysis [J]. J Periodontol, 2016, 87(3): 281-290.
[8] Jenabian N, Motallebnejad M, Zahedi E, et al. Coronally advanced flap and connective tissue graft with or without plasma rich in growth factors (PRGF) in treatment of gingival recession [J]. J Clin Exp Dent, 2018, 10(5): e431-e438.
[9] Ucak TO, Ozcan M, Alkaya B, et al. Clinical evaluation of injectable platelet-rich fibrin with connective tissue graft for the treatment of deep gingival recession defects: A controlled randomized clinical trial [J]. J Clin Periodontol, 2020, 47(1): 72-80.
[10] Lee HM, Shen EC, Shen JT, et al. Tensile strength, growth factor content and proliferation activities for two platelet concentrates of platelet-rich fibrin and concentrated growth factor [J]. J Dent Sci, 2020, 15(2): 141-146.
[11] Li J, Zheng L, Daraqel B, et al. The efficacy of concentrated growth factor and platelet-rich fibrin as scaffolds in regenerative endodontic treatment applied to immature permanent teeth: a retrospective study [J]. BMC Oral Health, 2023, 23(1): 482-482.
[12] Bozkurt DS, Ongoz DF, Balli U, et al. Concentrated growth factor in the treatment of adjacent multiple gingival recessions: a split-mouth randomized clinical trial [J]. J Clin Periodontol, 2015, 42(9): 868-875.
[13] Korkmaz B, Balli U. Clinical evaluation of the treatment of multiple gingival recessions with connective tissue graft or concentrated growth factor using tunnel technique: a randomized controlled clinical trial [J]. Clin Oral Investig, 2021, 25(11): 6347-6356.
[14] Griffin TJ, Cheung WS, Zavras AI, et al. Postoperative complications following gingival augmentation procedures [J]. J Periodontol, 2006, 77(12): 2070-2079.
[15] Akcan SK, Ünsal B. Gingival recession treatment with concentrated growth factor membrane: a comparative clinical trial [J]. J Appl Oral Sci, 2020, 28:e20190236.
[16] Keranmu D, Ainiwaer A, Nuermuhanmode N, et al. Application of concentrated growth factor to autotransplantation with inflammation in recipient area [J]. BMC Oral Health, 2021, 21(1): 556-556.
[17] Cairo F, Nieri M, Cincinelli S, et al. The interproximal clinical attachment level to classify gingival recessions and predict root coverage outcomes: an explorative and reliability study [J]. J Clin Periodontol, 2011, 38(7): 661-666.
[18] Chambrone L, Avila-Ortiz G. An evidence-based system for the classification and clinical management of non-proximal gingival recession defects [J]. J Periodontol, 2021, 92(3): 327-335.
[19] Kuralt M, Kučič AC, Gašperšič R, et al. Evaluation of gingival recessions with conventional versus digital methods [J]. J Dent, 2022, 120: 104093.
[20] Cairo F, Burkhardt R. Minimal invasiveness in gingival augmentation and root coverage procedures [J]. Periodontol 2000, 2023, 91(1):45-64.

CGF辅助治疗MillerⅠ类牙龈退缩的临床评价

Clinical Evaluation of CGF Assisted Treatment of Miller Class Ⅰ Gingival Recession

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	王静, 林华洁, 黄威, 殷金萍, 孟伟涛, 张筱娅. CGF在比格犬成熟恒牙根尖周炎愈合中的潜在作用研究[J]. 口腔医学研究, 2023, 39(7): 602-606.
[2]	赵琛, 姜杉杉, 刘阳, 吴素然, 邱桐, 白月辉, 吴洁, 贾语婧. 液态浓缩生长因子联合透明质酸注射治疗对颞下颌关节骨关节炎的影响[J]. 口腔医学研究, 2023, 39(4): 362-369.
[3]	戴嘉秀, 刘晓慧, 刘榆, 许舒宇. 基于体素的拟合测量比较CGF凝胶与CGF提取液进行牙槽嵴位点保存的疗效[J]. 口腔医学研究, 2022, 38(2): 129-133.
[4]	刘冬晓, 夏连松, 黄川. 软组织移植用于治疗正畸后牙龈退缩的临床疗效分析[J]. 口腔医学研究, 2021, 37(8): 708-711.
[5]	刘瑞敏, 鄢明东, 黄文秀, 吴东, 陈江. 上颌窦侧壁开窗提升术中应用CGF的骨增量影像学评价与临床对照研究[J]. 口腔医学研究, 2021, 37(2): 162-166.
[6]	梁源, 罗椸, 沈静涛, 王思, 周乔. 浓缩生长因子对游离龈移植术后供区创面愈合的效果评价[J]. 口腔医学研究, 2021, 37(12): 1135-1138.
[7]	刘春影, 周延民. 血小板浓缩物促进周围神经再生的研究进展[J]. 口腔医学研究, 2020, 36(6): 509-511.
[8]	于文凤, 赵世俊, 吕敏敏, 崔凤林, 康梅珍, 张志媛. 浓缩生长因子在上颌前牙区引导骨再生术中的临床应用[J]. 口腔医学研究, 2019, 35(7): 676-680.
[9]	葛林虎, 方颖, 查骏, 李军, 万绵佳, 王丽萍. 浓缩生长因子促进大鼠种植体骨结合的实验研究[J]. 口腔医学研究, 2018, 34(7): 721-725.
[10]	张慧慧, 李明丽, 李成章. 侧向转位瓣结合上皮下结缔组织移植治疗重度Miller Ⅲ°牙龈退缩1例[J]. 口腔医学研究, 2018, 34(5): 572-574.
[11]	王娜, 曲哲, 周宏志, 陈小冬. CGF在上颌窦外提升术中的临床应用效果评价[J]. 口腔医学研究, 2018, 34(2): 186-189.
[12]	罗婷苑，张森林. 浓缩生长因子促进骨再生的实验研究[J]. 口腔医学研究, 2017, 33(9): 954-957.
[13]	朱中焰, 张璐, 刘敏. 富自体浓缩生长因子纤维蛋白提取液对MC3T3-E1成骨细胞增殖与分化的影响[J]. 口腔医学研究, 2017, 33(11): 1147-1150.
[14]	付丽, 孙悦, 翟婧捷, 孙晓琳, 周延民. 3D打印及CGF在双侧下牙槽神经移位同期牙种植术中的应用[J]. 口腔医学研究, 2016, 32(10): 1003-1005.
[15]	朱妍菲,谢玉峰. 牙龈生物型的特点及其临床意义[J]. 口腔医学研究, 2015, 31(9): 945-948.