口腔医学研究

口腔医学研究 ›› 2021, Vol. 37 ›› Issue (12): 1135-1138.DOI: 10.13701/j.cnki.kqyxyj.2021.12.016

• 口腔种植学研究 • 上一篇    下一篇

浓缩生长因子对游离龈移植术后供区创面愈合的效果评价

梁源1,2, 罗椸1, 沈静涛1, 王思2,3, 周乔1,3   

  1. 1.重庆医科大学附属口腔医院种植科 重庆 401147;
    2.口腔疾病与生物医学重庆市重点实验室 重庆 401147;
    3.重庆市高校市级口腔生物医学工程重点实验室 重庆 401147
  • 收稿日期:2021-05-10 发布日期:2021-12-17
  • 通讯作者: *周乔,E-mail:500942@hospital.cqmu.edu.cn
  • 作者简介:梁源(1989~ )女,重庆人,学士,主管护师,研究方向:口腔种植学。
  • 基金资助:
    重庆市教育委员会科学技术研究项(编号:KJQN201900415)

Clinical Effect of CGF Application on Palatal Wound Healing after Free Gingival Graft Harvesting

LIANG Yuan1,2, LUO Yi1, SHEN Jingtao1, WANG Si2,3, ZHOU Qiao1,3   

  1. 1. Department of Dental Implantation, The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 401147, China;
    2. Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, China;
    3. Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China
  • Received:2021-05-10 Published:2021-12-17

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摘要： 目的:比较血小板衍生物浓缩生长因子(concentrated growth factor, CGF)与常规处理对于游离龈移植术后硬腭供区伤口愈合的临床效果。方法:选取就诊于重庆医科大学附属口腔医院行游离龈移植术的患者共计30例(对照组14例;CGF组16例),其中对照组在获取游离龈瓣后仅在供区位置缝合碘仿纱条,而CGF组则在硬腭供区创面覆盖CGF膜,随后缝合碘仿纱条。术后定期复诊,以患者术后创面愈合程度作为主要结局,患者创口的痛感、肿胀等主观感受以及牙龈的颜色质地等为次要结局,观察并统计相应临床结果。结果:CGF组在愈合面积上除术后3 d相较于对照组无显著性差异外(P=0.138),其余时间点均优于对照组(P＜0.05); 就术后供区愈合后的牙龈黏膜质地而言,CGF组在术后即刻、术后3 d和7 d均优于对照组(P＜0.05);就术后供区疼痛、肿胀而言,CGF组在术后各个时间点上给患者带来的主观感受均优于对照组(P＜0.05)。结论:与常规术后对供区的处理相比,CGF的覆盖促进了术后供区的伤口愈合与黏膜状态,且缓解了患者术后的疼痛、肿胀及不适,值得临床推广使用。

关键词: 浓缩生长因子, 伤口愈合, 疼痛, 游离龈移植

Abstract: Objective: To compare the healing effect between concentrated growth factor (CGF) membranes and conventional treatment for palatal wounds, resulting from free gingival graft (FGG) harvesting. Methods: Thirty patients requiring FGG were included in this study. After FGG harvesting, CGF group (n=16) received CGF membranes and iodoform sponges at the palatal wound while control group (n=14) only receiving iodoform sponges. Wound healing area of the palatal wound, mucosal condition, and postoperative pain were assessed 3, 7, 14, and 30 days after operation. Results: CGF group healed better on the palatal wound (P＜0.05) than that of control group except for 3 days of follow-up. As for postsurgical mucosal state, CGF group had more favorable outcomes immediately after operation and 3 and 7 days postoperation (P＜0.05). At 30 days postoperation, both groups showed total recovery. Further, control group experienced higher pain level and discomfort P＜0.05) until the 14th day. Conclusion: CGF membranes significantly promote the healing process and soothe the postsurgical pain for palatal wound healing.

Key words: concentrated growth factor, wound healing, pain, free gingival graft