浓缩生长因子对游离龈移植术后供区创面愈合的效果评价

doi:10.13701/j.cnki.kqyxyj.2021.12.016

口腔医学研究 ›› 2021, Vol. 37 ›› Issue (12): 1135-1138.DOI: 10.13701/j.cnki.kqyxyj.2021.12.016

浓缩生长因子对游离龈移植术后供区创面愈合的效果评价

梁源^1,2, 罗椸¹, 沈静涛¹, 王思^2,3, 周乔^1,3

1.重庆医科大学附属口腔医院种植科重庆 401147;
2.口腔疾病与生物医学重庆市重点实验室重庆 401147;
3.重庆市高校市级口腔生物医学工程重点实验室重庆 401147

收稿日期:2021-05-10 发布日期:2021-12-17
通讯作者: *周乔,E-mail:500942@hospital.cqmu.edu.cn
作者简介:梁源(1989~ )女,重庆人,学士,主管护师,研究方向:口腔种植学。
基金资助:
重庆市教育委员会科学技术研究项(编号:KJQN201900415)

Clinical Effect of CGF Application on Palatal Wound Healing after Free Gingival Graft Harvesting

LIANG Yuan^1,2, LUO Yi¹, SHEN Jingtao¹, WANG Si^2,3, ZHOU Qiao^1,3

1. Department of Dental Implantation, The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 401147, China;
2. Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, China;
3. Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China

Received:2021-05-10 Published:2021-12-17

摘要/Abstract

摘要： 目的:比较血小板衍生物浓缩生长因子(concentrated growth factor, CGF)与常规处理对于游离龈移植术后硬腭供区伤口愈合的临床效果。方法:选取就诊于重庆医科大学附属口腔医院行游离龈移植术的患者共计30例(对照组14例;CGF组16例),其中对照组在获取游离龈瓣后仅在供区位置缝合碘仿纱条,而CGF组则在硬腭供区创面覆盖CGF膜,随后缝合碘仿纱条。术后定期复诊,以患者术后创面愈合程度作为主要结局,患者创口的痛感、肿胀等主观感受以及牙龈的颜色质地等为次要结局,观察并统计相应临床结果。结果:CGF组在愈合面积上除术后3 d相较于对照组无显著性差异外(P=0.138),其余时间点均优于对照组(P＜0.05); 就术后供区愈合后的牙龈黏膜质地而言,CGF组在术后即刻、术后3 d和7 d均优于对照组(P＜0.05);就术后供区疼痛、肿胀而言,CGF组在术后各个时间点上给患者带来的主观感受均优于对照组(P＜0.05)。结论:与常规术后对供区的处理相比,CGF的覆盖促进了术后供区的伤口愈合与黏膜状态,且缓解了患者术后的疼痛、肿胀及不适,值得临床推广使用。

关键词: 浓缩生长因子, 伤口愈合, 疼痛, 游离龈移植

Abstract: Objective: To compare the healing effect between concentrated growth factor (CGF) membranes and conventional treatment for palatal wounds, resulting from free gingival graft (FGG) harvesting. Methods: Thirty patients requiring FGG were included in this study. After FGG harvesting, CGF group (n=16) received CGF membranes and iodoform sponges at the palatal wound while control group (n=14) only receiving iodoform sponges. Wound healing area of the palatal wound, mucosal condition, and postoperative pain were assessed 3, 7, 14, and 30 days after operation. Results: CGF group healed better on the palatal wound (P＜0.05) than that of control group except for 3 days of follow-up. As for postsurgical mucosal state, CGF group had more favorable outcomes immediately after operation and 3 and 7 days postoperation (P＜0.05). At 30 days postoperation, both groups showed total recovery. Further, control group experienced higher pain level and discomfort P＜0.05) until the 14th day. Conclusion: CGF membranes significantly promote the healing process and soothe the postsurgical pain for palatal wound healing.

Key words: concentrated growth factor, wound healing, pain, free gingival graft

梁源, 罗椸, 沈静涛, 王思, 周乔. 浓缩生长因子对游离龈移植术后供区创面愈合的效果评价[J]. 口腔医学研究, 2021, 37(12): 1135-1138.

LIANG Yuan, LUO Yi, SHEN Jingtao, WANG Si, ZHOU Qiao. Clinical Effect of CGF Application on Palatal Wound Healing after Free Gingival Graft Harvesting[J]. Journal of Oral Science Research, 2021, 37(12): 1135-1138.

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浓缩生长因子对游离龈移植术后供区创面愈合的效果评价

Clinical Effect of CGF Application on Palatal Wound Healing after Free Gingival Graft Harvesting

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