骨组织工程学支架用于下颌骨缺损修复的研究进展

doi:10.13701/j.cnki.kqyxyj.2026.06.001

摘要/Abstract

摘要： 下颌骨是颅颌面骨的重要组成部分,其在吞咽、呼吸中的关键力学作用、独特的膜内成骨起源、高重塑活性及骨髓干细胞特有的强成骨潜能,使其组织工程修复有着区别于长骨的独特挑战。本综述系统探讨了下颌骨组织工程修复的核心策略与技术进展,包括支架材料与设计、生物活性增强策略、目前的研究难点以及4D技术的发展潜力等。本文旨在为开发高效、安全、功能性的下颌骨再生修复方案提供理论依据和技术参考。

关键词: 下颌骨缺损修复, 组织工程, 支架, 4D打印

Abstract: The mandible is a vital component of the craniofacial bone. Due to its critical biomechanical roles, unique intramembranous ossification process, high bone remodeling activity, and the robust osteogenic potential of mandibular bone marrow mesenchymal stem cells (BMSCs), tissue engineering strategies for mandibular repair present distinct challenges compared to those used for long bones. This review provides a systematic overview of key strategies and technological advances in mandibular tissue engineering. It covers scaffold materials and design, bioactive enhancement approaches, current research challenges, and the emerging potential of 4D printing and related technologies. The objective of this review is to offer a theoretical foundation and technical guidance for the development of effective, safe, and functionally integrated regenerative solutions for mandibular bone defects.

Key words: mandibular defect repair, tissue engineering, stent, 4D printing technology

李东阳, 李军. 骨组织工程学支架用于下颌骨缺损修复的研究进展[J]. 口腔医学研究, 2026, 42(6): 461-466.

LI Dongyang, LI Jun. Mandibular Bone Regeneration: Evolving Strategies in Tissue Engineering Scaffold Design[J]. Journal of Oral Science Research, 2026, 42(6): 461-466.

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