口腔医学研究

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (2): 150-153.DOI: 10.13701/j.cnki.kqyxyj.2016.02.011

• ·临床研究论著· • 上一篇    下一篇

牙周感染对脑梗死患者APP及IL-6水平的影响

张正1,2 张莉3 郑友丽4 马宁1*   

  1. 1. 吉林大学口腔医院牙周科 吉林 长春 130021;
    2. 南开大学口腔医院·天津市口腔医院牙周科 天津 300000;
    3. 吉林大学口腔医院急诊科 吉林 长春 130021;
    4. 天津医科大学口腔医院综合科 天津 300000
  • 收稿日期:2015-07-06 出版日期:2016-02-28 发布日期:2016-03-10
  • 通讯作者: 马宁,E-mail:maningbsh76@sina.com
  • 作者简介:张正(1985~),男,安徽淮北人,医学硕士,主要从事牙周病病因及防治等方面的研究
  • 基金资助:
    吉林省自然科学基金项目(项目编号:201115107)

Effect of Periodontal Infection on APP and IL-6 Levels in Patients with Cerebral Infarction.

ZHANG Zheng1,2, ZHANG Li3, ZHENG You-li4, MA Ning1.   

  1. 1. Department of Periodontology, Stomatological Hospital, Jilin University, Changchun 130021, China;
    2. Department of Periodontology, Tianjin Stomatological Hospital, Nankai University, Tianjin 300000, China;
    3. Department of Emergency, Stomatological Hospital, Jilin University, Changchun 130021, China;
    4. Deptartment of General Dentistry, Stomatological Hospital, Tianjin Medical University, Tianjin 300000, China.
  • Received:2015-07-06 Online:2016-02-28 Published:2016-03-10

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摘要： 目的:探讨急性脑梗死患者急性期反应蛋白(acute phase protein, APP)和白介素-6(interleukin-6, IL-6)水平的变化,以及牙周感染的全身抗体反应对脑梗死患者APP及IL-6水平的影响。方法:随机选择首次发作急性脑梗死患者88例,健康对照组40例,并依据牙龈卟啉单胞菌IgG抗体(P.g-IgG)水平高低分为Pg-IgG抗体阳性[Pg-IgG(+)]组与Pg-IgG抗体阴性[Pg-IgG(-)]组。分别利用酶联免疫吸附试验和全自动血凝分析仪检测各组受试者超敏C反应蛋白(high-sensitivity C-reactive protein,Hs-CRP)、纤维蛋白原(fibrinogen, Fg)以及IL-6的血清浓度。结果:急性脑梗死患者Hs-CRP、Fg以及IL-6明显高于健康受试者;Pg-IgG(+)组Hs-CRP和IL-6明显高于Pg-IgG(-)组;Hs-CRP和IL-6与Pg-IgG正相关。结论:牙龈卟啉单胞菌的全身扩散或其引起的全身抗体反应可通过促进Hs-CRP和IL-6水平的升高而增加脑梗死的患病风险。

关键词: 脑梗死, 牙周炎, 抗体, 急性期反应蛋白, 白介素-6

Abstract: Objective: To study the changes of acute phase protein (APP) and interleukin-6 (IL-6) levels in patients with cerebral infarction and effect of systemic antibody response of periodontal infection on APP and IL-6 levels.Methods: Eighty-eight patients with acute cerebral infarction for the first time and forty healthy subjects were included in this study. The subjects were grouped into Pg-IgG antibody positive [Pg-IgG (+) ] group and Pg-IgG antibody negative [Pg-IgG(-)] group according to Porphyromonas gingivalis IgG (P.g-IgG) levels. Serum high-sensitivity C-reactive protein (Hs-CRP), fibrinogen (Fg) and IL-6 levels were detected by enzyme-linked immune sorbent assay method and automatic blood coagulation analyzer. Results: Hs-CRP, Fg and IL-6 were significantly higher in patients with acute cerebral infarction than healthy subjects. Hs-CRP and IL-6 were significantly higher in Pg-IgG (+) group than that in Pg-IgG (-) group. Hs-CRP and IL-6 were positively correlated with Pg-IgG. Conclusion: Periodontal Porphyromonas gingivalis infection may increase cerebral infarction risk by promoting the levels of Hs-CRP and IL-6.

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