整合素连接激酶和基质金属蛋白酶-9在涎腺腺样囊性癌中的表达及意义

doi:10.13701/j.cnki.kqyxyj.2016.07.025

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (7): 764-767.DOI: 10.13701/j.cnki.kqyxyj.2016.07.025

整合素连接激酶和基质金属蛋白酶-9在涎腺腺样囊性癌中的表达及意义

靳勇勇

焦煤集团中央医院口腔科河南焦作 454000

收稿日期:2015-09-28 出版日期:2016-07-26 发布日期:2016-07-25
作者简介:靳勇勇(1982~ ),男,学士,主治医师,主要从事口腔修复种植的临床治疗工作,电话:13203912436。

Expression and Significance of Integrin-linked Kinase and Matrix Metalloproteinase-9 in Salivary Adenoid Cystic Carcinoma.

JIN Yong-yong

Department of Stomatology, Jiaomei Central Hospital, Jiaozuo 454150, China

Received:2015-09-28 Online:2016-07-26 Published:2016-07-25

摘要/Abstract

摘要： 目的: 探讨整合素连接激酶(ILK)和基质金属蛋白酶-9(MMP-9)在涎腺腺样囊性癌(SACC)中的表达及意义。方法: 选取59例SACC患者和42例非肿瘤患者正常涎腺组织,利用qRT-PCR技术检测ILK和MMP-9在SACC组织中表达。结果: SACC组织中ILK mRNA和MMP-9 mRNA相对表达量均高于对照组,差异均有统计学意义(P<0.05);ILK和MMP-9在SACC组织中表达均与组织类型、淋巴结转移、TNM分期有关(P<0.05),实体型和管状型SACC组织中ILK mRNA和MMP-9 mRNA相对表达量均高于筛状型(P<0.05);Pearson相关分析显示,SACC组织中ILK mRNA相对表达量与MMP-9 mRNA相对表达量呈正相关(r=0.586,P=0.000)。结论: ILK和MMP-9在SACC组织中呈高表达,可能共同协同参与了肿瘤细胞侵袭、转移过程。

关键词: 涎腺腺样囊性癌, 整合素连接激酶, 基质金属蛋白酶-9, 表达

Abstract: Objective: To investigate the expression and significance of integrin-linked kinase (ILK) and matrix metalloproteinase-9 (MMP-9) in salivary adenoid cystic carcinoma (SACC). Methods: 59 cases of SACC specimens and 42 cases of normal salivary gland tissues were collected. The expression of ILK and MMP-9 in SACC and normal tissues were detected by using QRT-PCR technology. Results: The mRNA expression levels of ILK and MMP-9 were significantly higher in SACC tissues than those in control group (P<0.05), and they were positively correlated in SACC tissues (r=0.586, P=0.000). The expression of ILK and MMP-9 in SACC tissues were correlated with disease subtype, lymph node metastasis and TNM stage (P<0.05). The mRNA expression levels of ILK and MMP-9 in entity and tubular type were obviously higher than sieve-like type (P<0.05). Conclusion: Up-regulation of ILK and MMP-9 may synergistically promote the invasion and metastasis of tumor cells in SACC.

Key words: Salivary adenoid cystic carcinoma, Integrin-linked kinase , Matrix metalloproteinase-9, Expression

中图分类号:

R739.8

靳勇勇. 整合素连接激酶和基质金属蛋白酶-9在涎腺腺样囊性癌中的表达及意义[J]. 口腔医学研究, 2016, 32(7): 764-767.

JIN Yong-yong. Expression and Significance of Integrin-linked Kinase and Matrix Metalloproteinase-9 in Salivary Adenoid Cystic Carcinoma.[J]. Journal of Oral Science Research, 2016, 32(7): 764-767.

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整合素连接激酶和基质金属蛋白酶-9在涎腺腺样囊性癌中的表达及意义

Expression and Significance of Integrin-linked Kinase and Matrix Metalloproteinase-9 in Salivary Adenoid Cystic Carcinoma.

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