微生态制剂及抗菌肽在龋病防治中的研究进展

doi:10.13701/j.cnki.kqyxyj.2016.09.026

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (9): 994-996.DOI: 10.13701/j.cnki.kqyxyj.2016.09.026

微生态制剂及抗菌肽在龋病防治中的研究进展

汪珍珍¹,余占海¹,吕玮¹,周建业²,胡晓潘²,焦康礼²,李志强^2*

1. 兰州大学口腔医学院修复科甘肃兰州 730000;
2. 西北民族大学口腔医学国家民委重点实验室甘肃兰州 730030

收稿日期:2015-08-18 出版日期:2016-09-26 发布日期:2016-09-26
通讯作者: 李志强,E-mail: lizhiqiang6767@163.com
作者简介:汪珍珍(1988~ ),女,宁夏石嘴山人,硕士在读,主要从事口腔修复及口腔微生物群落结构多样性研究。
基金资助:
国家自然科学基金地区基金项目(编号:31360124/C0309,31160124/C0309)

Research Progress of Probiotics and Antimicrobial Peptides in Caries Prevention

WANG zhen-zhen^1*, YU Zhan-hai¹, LV Wei¹, ZHOU Jian-ye², HU Xiao-pan², Jiao Kang-li², LI Zhi-qiang²

1. School of Stomatology,Lanzhou University,Lanzhou 730000,China;
2. Key Laboratory of State Ethnic Affairs Commission of Stomatology,Northwest University For Nationalities,Lanzhou 730030,China

Received:2015-08-18 Online:2016-09-26 Published:2016-09-26

摘要/Abstract

摘要： 龋病是以细菌因素为主的多种因素引起的口腔微生态失衡为特征的口腔慢性感染性疾病,是人类最常见的细菌性疾病^[1,2]。目前龋病预防的关注点集中于对牙菌斑的去除,而牙菌斑实则为大量共生微生物集中组成,因此"移除或杀灭所有"菌斑微生物的理念对于致病微生物创造了一个开放的非竞争性的环境。传统的方法预防或治疗龋病,无法从根本上解决牙体组织损伤及细菌耐药性等问题。微生态制剂及抗菌肽应运而生,通过抑制口腔病原菌毒性作用以达到调节口腔微生态平衡的目的,是预防及治疗龋病的新方法。

关键词: 龋病, 益生菌, 细菌替代治疗, 抗菌肽

Abstract: Dental caries, the most common bacterial diseases for mankind, is oral chronic infection disease that under the combined action of various factors to bacterial factors and is characterized by oral microbial ecology imbalance. Because dental plaque is prerequisites of caries, at present, the focus of dental caries prevention is still concentrated in removing dental plaque that is composed of a large number of symbiotic microorganisms actually. Therefore, an idea to "remove or kill" all the microorganisms in dental plaque oppositely creates an open and non-competitive environment for pathogenic microorganisms. People gradually realize that the traditional method of prevention or treatment of dental caries is unable to fundamentally solve not reversible tooth tissue damage and bacterial resistance. Probiotics and antimicrobial peptide are present at the right moment. They regulate the oral microbial ecology balance through the inhibition of toxic effects of oral pathogenic bacteria. Now, it has become the new method to prevent and treat dental caries.

Key words: Caries, Probiotics, Replacement therapy, Antimicrobial peptide

中图分类号:

R780.1

汪珍珍,余占海,吕玮,周建业,胡晓潘,焦康礼,李志强. 微生态制剂及抗菌肽在龋病防治中的研究进展[J]. 口腔医学研究, 2016, 32(9): 994-996.

WANG zhen-zhen,YU Zhan-hai,LV Wei,ZHOU Jian-ye,HU Xiao-pan,Jiao Kang-li,LI Zhi-qiang. Research Progress of Probiotics and Antimicrobial Peptides in Caries Prevention[J]. Journal of Oral Science Research, 2016, 32(9): 994-996.

参考文献

[1] Wade WG . The oral microbiome in health and disease [J]. Pharmacological Research, 2013, 69(1)∶138-143
[2] World Health Organization: Oral health fact sheet N°318.2012 In: Centre, M (ed.)
[3] Bhardwaj A, Bhardwaj SV. Role of Probiotics in Dental Caries and Periodontal Disease [J]. Archive of Clinical and Experimental, 2012, 43(1)∶45-49
[4] Gungor OE, Kirzioglu Z, Kivanc M. Probiotics: can they be used to improve oral health [J]. Beneficial Microbes, 2015, 47(1)∶1-10
[5] Saini R, Saini S, Sharma S. Potential of probiotics in controlling cardiovascular diseases [J]. Cardiovasc Dis Res,2010,1∶213-214
[6] Chong ES. A potential role of probiotics in colorectal cancer prevention: review of possible mechanisms of action [J]. World J Microbiol Biotechnol, 2014, 30∶351-374
[7] Reid G, Bruce AW, Fraser N, et al. probiotics can resolve urogenital infections [J]. FEMS Immunol Med Microbiol, 2001, 30∶49-52
[8] Raman M, Ambalam P, Kondepudi KK, et al. Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer [J]. Gut Microbes, 2013, 4∶181-192
[9] Masdea L, Kilik EM, Hauser-Gerspach, et al. Antimicrobial activity of Streptococcus salivarius K12 on bacteria involved in oral malodou [J]. Archives of oral biology, 2012, 57∶1041-1047
[10] Terai T, Okumura T, Imai S, Nakao M, Yamaji K, Ito M, et al. Screening of Probiotic Candidates in Human Oral Bacteria for the Prevention of Dental Disease [J]. PLoS ONE,2015,10(6)∶e0128657
[11] Marttinen A, Haukioja A, Karjalainen S, et al. Short-term consumption of probiotic lactobacilli has no effect on acid production of supragingival plaque [J]. Clin Oral Investig,2012,16∶797-803
[12] Singh RP, Damle SG, Chawla A, et al. Salivary mutans streptococci and lactobacilli modulations in young children on consumption of probiotic ice-cream containing Bifidobacterium lactis Bb12 and Lactobacillus acidophilus La5 [J]. Acta Odontol Scand,2011,69∶389-394
[13] Chuang LC, Huang CS, Ou-Yang LW,et al. Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora [J]. Clin Oral Investig,2011,15∶471-476
[14] Jindal G, Pandey RK, Agarwal J,et al. A comparative evaluation of probiotics on salivary mutans streptococci counts in Indian children [J]. Eur Arch Paediatr Dent, 2011, 12∶211-215
[15] Chuang LC, Huang CS, Ou-Yang LW, et al. Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora [J]. Clin Oral Investig, 2011, 15∶471-476
[16] Onnida Wattanarat, Anupong Makeudom, Thanapat Sastraruji, et al. Enhancement of salivary human neutrophil peptide 1 - 3 levels by probiotic supplementation [J]. BMC Oral Heath,2015,15∶19
[17] Singh RP, Damle SG, Chawla A. Salivary mutans streptococci and lactobacilli modulations in young children on consumption of probiotic ice-cream containing Bifidobacterium lactis Bb12 and Lactobacillus acidophilus La5 [J]. Acta Odontol Scand, 2011, 69∶389-394
[18] Bhushan J, Chachra S. Probiotics. Their Role in Prevention of Dental Caries [J]. J Oral Health Comm Dent,2010,4(3)∶78-82
[19] W. Pan, T. Mao, Q. Xu, et al.A New gcr R - Deficient Streptococcus mutans Mutant for Replacement Therapy of Dental Caries [J]. The Scientific World Journal,2013,2013∶1-7
[20] Nascimento MM, Gordan VV, Garvan CW, et al. Correlations of oral bacterial arginine and urea catabolism with caries experience [J]. Oral Microbiol Immunol, 2009, 24∶89-95
[21] Wu G, Bazer FW, Davis TA, et al. Arginine metabolism and nutrition in growth,health and disease [J]. Amino Acids, 2009, 37∶153-168
[22] Sharif MO, Iram S, Brunton PA Effectiveness of argininecontaining toothpastes in treating dentine hypersensitivity: a systematic review [J]. J Dent ,2013, 41∶483-492
[23] unni. Mai, X.L. Tian, J.W. Gallant, et al. A Novel Target-Specific, Salt-Resistant Antimicrobial Peptide against the Cariogenic Pathogen Streptococcus mutans [J]. Antimicrobial Agents And Chemotherapy,2011,55(11)∶5205-5213
[24] Kaplan CW, Sim JH, Shah KR, et al. Selective membrane disruption: mode of action of C16G2, a specifically targetedantimicrobial peptide [J]. Antimicrobial Agents And Chemotherapy,2011,55(7)∶3446-3452
[25] Cagetti MG, Mastroberardino S, Milia E, et al. The Use of Probiotic Strains in Caries Prevention A Systematic Review [J]. Nutrients,2013,5(7)∶2530-2550

微生态制剂及抗菌肽在龋病防治中的研究进展

Research Progress of Probiotics and Antimicrobial Peptides in Caries Prevention

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