口腔菌群多样性与菌株基因组多态性

doi:10.13701/j.cnki.kqyxyj.2019.10.001

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (10): 915-918.DOI: 10.13701/j.cnki.kqyxyj.2019.10.001

• 特约述评 • 下一篇

口腔菌群多样性与菌株基因组多态性

葛林虎^*, 苏汉福

广州医科大学附属口腔医院,广州口腔疾病研究所,口腔医学重点实验室广东广州 510182

收稿日期:2019-07-11 出版日期:2019-10-28 发布日期:2019-10-22
通讯作者: 葛林虎,E-mail:gelinhu@yeah.net
作者简介:葛林虎,医学博士,研究生导师,现任广州医科大学附属口腔医院院长,兼任中华口腔医学会理事,中华口腔医学会口腔医学教育专业委员会委员,中国整形美容协会口腔整形美容分会常务理事,粤港澳大湾区口腔健康联盟常务副主任委员(兼秘书长),广东省口腔医学会副会长,广东省医师协会口腔医师分会副主任委员,广州市医学会口腔医学分会主任委员,广州市3D打印技术产业联盟副理事长。主要从事非编码RNA与口腔肿瘤的关系研究,口腔微生态与全身系统性疾病研究,主持和参与多项国家级、省部级重点课题,发表论文40余篇,总编出版专著17部,实用新型专利1件。

Oral Microbiota Diversity and Bacterial Genomic Polymorphism.

GE Linhu^*, SU Hanfu

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou 510182, China.

Received:2019-07-11 Online:2019-10-28 Published:2019-10-22

摘要/Abstract

摘要： 口腔菌群是口腔中所有细菌的集合,其不仅在牙周病、龋病等口腔炎症性疾病中具有关键作用,还与动脉粥样硬化、阿尔兹海默症、类风湿性关节炎等口腔外疾病相关。然而,口腔菌群在个体间存在很大的差异。这种差异既表现在群体组成上(多样性),又表现在细菌基因组上(多态性)。口腔菌群多样性和多态性是影响疾病发生发展的重要原因,也是口腔菌群与健康关系研究的重点。本文就目前口腔菌群多样性与多态性研究进展及其在疾病中的作用做一述评。

关键词: 口腔菌群, 多样性, 多态性, 疾病

Abstract: Oral microbiota is the combination of all bacteria living in oral cavity. Recent evidence showed that oral microbiota not only plays key role on oral diseases such as periodontitis and dental caries, but also is associated with systemic diseases like atherosclerosis, Alzheimer's disease, and rheumatoid arthritis. Oral microbiota differs in both bacterial population (diversity) and bacterial genomes (polymorphism) among individuals, which are important factors that impact diseases development. This paper reviews recent progress in understanding of oral microbiota in the aspect of diversity and polymorphism, and their roles in disease development.

Key words: oral microbiota, diversity, polymorphism, disease

葛林虎, 苏汉福. 口腔菌群多样性与菌株基因组多态性[J]. 口腔医学研究, 2019, 35(10): 915-918.

GE Linhu, SU Hanfu. Oral Microbiota Diversity and Bacterial Genomic Polymorphism.[J]. Journal of Oral Science Research, 2019, 35(10): 915-918.

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口腔菌群多样性与菌株基因组多态性

Oral Microbiota Diversity and Bacterial Genomic Polymorphism.

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