种植体周围炎大鼠模型研究

doi:10.13701/j.cnki.kqyxyj.2021.04.009

摘要/Abstract

摘要： 目的: 改良大鼠种植体周围炎模型,简化造模步骤,缩短造模时间。方法: 拔除16只大鼠上颌第一磨牙,拔牙窝愈合1个月后植入钛种植体。种植体骨结合4周后用丝线结扎诱导炎症并糖水喂养。结扎后2周观察炎症诱导情况。处死大鼠,取上颌骨拍摄X线片用于影像学分析。制作骨组织切片和提取种植体周围牙龈组织进行免疫组化分析。结果: 结扎2周后种植体周围炎诱导成功,种植体周围不仅有软组织炎症,还有不同程度骨组织吸收。结论: 大鼠种植体周围炎模型改良成功,造模方便,造模周期短。

关键词: 种植体周围炎, 大鼠, 钛种植体, 骨结合

Abstract: Objective: To simplify the steps and shorten the time of reconstruction of rat peri-implantitis model. Methods: The maxillary first molars of 16 rats were extracted, and titanium implants were implanted one month later. After 4 weeks, silk thread ligation was used to induce inflammation and the rats were fed with sugar water. Two weeks later, the rats were sacrificed, the maxilla was taken X-rays for imaging analysis, bone tissue slices were made, and the gingival tissue around the implant was extracted for immunohistochemical analysis. Results: Two weeks after ligation, peri-implantitis was successfully induced. There was not only soft tissue inflammation around the implant, but also bone tissue resorption at various degrees. Conclusion: The model of rat peri-implantitis has been successfully constructed, with convenience and short modeling cycle.

Key words: peri-implantitis, rat, titanium implant, osseointegration

李星佳, 陈琪欣, 袁长永, 王鹏来. 种植体周围炎大鼠模型研究[J]. 口腔医学研究, 2021, 37(4): 314-318.

LI Xingjia, CHEN Qixin, YUAN Changyong, WANG Penglai. Modification of Rat Model with Peri-implantitis[J]. Journal of Oral Science Research, 2021, 37(4): 314-318.

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