口腔微生物与炎症性肠病关系的研究进展

doi:10.13701/j.cnki.kqyxyj.2022.06.001

口腔医学研究 ›› 2022, Vol. 38 ›› Issue (6): 491-496.DOI: 10.13701/j.cnki.kqyxyj.2022.06.001

• 特约述评 • 下一篇

口腔微生物与炎症性肠病关系的研究进展

闫福华^*, 张杨珩, 钱俊

南京大学医学院附属口腔医院江苏南京 210008

收稿日期:2021-12-25 出版日期:2022-06-28 发布日期:2022-06-23
通讯作者: * 闫福华,E-mail: yanfh@nju.edu.cn
作者简介:闫福华,南京大学医学院附属口腔医院副院长、教授、博士生导师。中华口腔医学会牙周病学专业委员会主任委员,中国医师协会口腔医师分会副会长,江苏省口腔医学会副会长,享受国务院政府特殊津贴专家。“十三五”规划教材《牙周病学》副主编。主要研究领域为:牙周病与系统性疾病的关系、组织工程与牙周再生治疗、牙周病的种植修复治疗等。主持省部级及以上科研项目15项,其中国家自然科学基金项目7项;发表论文300余篇,其中《Bioactive materials》、《Biomaterials》、《Theranostics》、《Applied Materials Today》、《Journal of Dental Research》、《Journal of Periodontology》等学术刊物 80余篇。主编、主译学术专著25部。获省级科学技术进步奖二等奖1项,教育部科技进步奖二等奖1项,江苏省医学新技术引进一等奖1项。
基金资助:
国家自然科学基金(编号:81970939)；南京口腔疾病临床医学研究中心项目(编号:2019060009) ；江苏省医学创新团队(编号:CXTDB2017014)

Research Progress in the Correlation between Oral Microbiota and Inflammatory Bowel Disease

YAN Fuhua^*, ZHANG Yangheng, QIAN Jun

Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China

Received:2021-12-25 Online:2022-06-28 Published:2022-06-23

摘要/Abstract

摘要： 炎症性肠病(inflammatory bowel disease, IBD)是一类以慢性、复发性炎症反应和肠道损伤为特征的疾病,目前其发病机制尚未完全清楚。近年来,IBD与口腔疾病的相关性引起了人们的关注。许多证据提示口腔微生物可能参与了IBD的发生发展。口腔中一些特定细菌可能会易位定植于肠道,影响肠道微生态平衡、破坏肠道屏障和引起异常的免疫炎症反应,从而影响IBD的疾病进程。研究IBD相关的口腔菌群特点以及关键的致病菌,可为IBD的辅助诊断和治疗策略提供新思路。

关键词: 口腔微生物, 炎症性肠病, 菌群调控

Abstract: Inflammatory bowel disease (IBD) is a type of disease characterized by chronic and recurrent inflammatory reactions and intestinal damage, but its pathogenesis remains unclear. In recent years, the correlation between IBD and oral diseases has aroused more and more attention. Many evidences suggest that oral microorganisms may be involved in the development of IBD. Some specific bacteria in the oral cavity may translocate and colonize the intestinal tract, affecting the intestinal microbe, destroying the intestinal barrier, and causing abnormal immune reactions, and then affect the development of IBD. The study of characteristics of IBD-related oral flora and key pathogens can provide new ideas for diagnosis and treatment of IBD.

Key words: oral microbiota, inflammatory bowel disease, microbiological regulation

闫福华, 张杨珩, 钱俊. 口腔微生物与炎症性肠病关系的研究进展[J]. 口腔医学研究, 2022, 38(6): 491-496.

YAN Fuhua, ZHANG Yangheng, QIAN Jun. Research Progress in the Correlation between Oral Microbiota and Inflammatory Bowel Disease[J]. Journal of Oral Science Research, 2022, 38(6): 491-496.

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口腔微生物与炎症性肠病关系的研究进展

Research Progress in the Correlation between Oral Microbiota and Inflammatory Bowel Disease

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