乳牙牙髓干细胞在口腔颌面疾病治疗中的应用

doi:10.13701/j.cnki.kqyxyj.2022.07.004

摘要/Abstract

摘要： 乳牙牙髓干细胞(stem cells from human exfoliated deciduous teeth,SHEDs)是一种牙源性间充质干细胞,来源易获取,扩增效率高,可以分化成多种细胞,并形成不同组织,还能分泌多种功能性细胞活性因子,具有调节免疫、抗细胞凋亡、促进组织修复和再生等多种功能。随着对SHEDs的研究的不断深入,发现 SHEDs 在治疗难治性疾病中具有一定的潜能,被认为是组织工程和干细胞治疗中颇具应用前景的种子细胞之一。本文主要阐述 SHEDs 的生物学特性和优势,并对其在口腔颌面部疾病中的应用及研究进展展开论述。

关键词: 乳牙牙髓干细胞, 口腔疾病, 组织再生

Abstract: Stem cells from human exfoliated deciduous teeth (SHEDs), a kind of odontogenic mesenchymal stem cells characterized by easy acquisition and high expansion efficiency, can differentiate into a variety of cells, form different tissues, and secrete a range of functional cellular activity factors. They can also regulate immunity, resist apoptosis, and facilitate tissue repair and regeneration. With diversified and intense research, the potential of SHEDs in the treatment of refractory diseases has been established, and SHEDs are now considered as one of the promising seed cells in tissue engineering and stem cell therapy. This study aims to elaborate the biological characteristics and advantages of SHEDs, and discuss their use in oral-maxillofacial diseases and research progress.

Key words: stem cells from human exfoliated deciduous teeth, oral diseases, tissue regeneration

潘露, 梁燕. 乳牙牙髓干细胞在口腔颌面疾病治疗中的应用[J]. 口腔医学研究, 2022, 38(7): 605-608.

PAN Lu, LIANG Yan. Application of Stem Cells from Human Exfoliated Deciduous Teeth in the Treatment of Oral and Maxillofacial Diseases[J]. Journal of Oral Science Research, 2022, 38(7): 605-608.

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