口腔细菌胞外囊泡在菌群-宿主交互中的作用与机制

doi:10.13701/j.cnki.kqyxyj.2026.09.001

口腔医学研究 ›› 2026, Vol. 42 ›› Issue (9): 733-739.DOI: 10.13701/j.cnki.kqyxyj.2026.09.001

• 综述 • 下一篇

口腔细菌胞外囊泡在菌群-宿主交互中的作用与机制

龚浩晨^1,2, 周婕妤^1,3*

1.口腔疾病防治全国重点实验室国家口腔医学中心口腔疾病国家临床医学研究中心四川成都 610041;
2.四川大学华西口腔医学院四川成都 610041;
3.四川大学华西口腔医院牙周病科四川成都 610041

收稿日期:2025-10-10 出版日期:2026-09-28 发布日期:2026-09-22
通讯作者: * 周婕妤,E-mail: zhoujieyu@scu.edu.cn
作者简介:龚浩晨(2004~ ),男,四川峨边人,本科在读,研究方向:口腔微生物学。
基金资助:
国家自然科学基金青年科学基金项目(编号:82301089);四川大学华西口腔医院探索与研发项目(编号:RD-02-202407)

Role and Mechanisms of Oral Bacterial Extracellular Vesicles in Microbiota-host Interactions

GONG Haochen^1,2, ZHOU Jieyu^1,3*

1. National Key Laboratory of Oral Diseases Prevention and Treatment & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Chengdu 610041, China;
2. West China School of Stomatology, Sichuan University, Chengdu 610041, China;
3. Department of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2025-10-10 Online:2026-09-28 Published:2026-09-22

摘要/Abstract

摘要： 细菌胞外囊泡(bacterial extracellular vesicles, BEVs)是近年来口腔疾病机制研究关注的热点之一,BEVs可通过介导菌群-宿主互作,直接参与牙周病、龋病及口腔癌等的发生发展。此类研究深化了对口腔疾病发病机制的理解,并为靶向防治策略提供了新方向。本文系统综述BEVs在菌群-宿主相互作用中的作用机制,重点阐明其与上述疾病的分子关联,并探讨其在口腔疾病预防与靶向治疗中的前沿应用。

关键词: 口腔菌群, 胞外囊泡, 菌群-宿主交互, 口腔疾病

Abstract: Bacterial extracellular vesicles (BEVs) are pivotal in oral disease pathogenesis. Research demonstrates their critical role in microbiota-host interactions, directly driving the development of periodontitis, dental caries, and oral cancer. These insights refine pathogenic models and inform novel targeted interventions. This review systematically summarizes BEV-mediated interaction mechanisms, analyzes their molecular roles in specific oral diseases, and explores translational applications in prevention and targeted therapy.

Key words: oral microbiota, extracellular vesicles, microbiota-host interactions, oral diseases

龚浩晨, 周婕妤. 口腔细菌胞外囊泡在菌群-宿主交互中的作用与机制[J]. 口腔医学研究, 2026, 42(9): 733-739.

GONG Haochen, ZHOU Jieyu. Role and Mechanisms of Oral Bacterial Extracellular Vesicles in Microbiota-host Interactions[J]. Journal of Oral Science Research, 2026, 42(9): 733-739.

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口腔细菌胞外囊泡在菌群-宿主交互中的作用与机制

Role and Mechanisms of Oral Bacterial Extracellular Vesicles in Microbiota-host Interactions

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