趋化因子受体CXCR7在牙周炎中的表达及其作用机制

doi:10.13701/j.cnki.kqyxyj.2020.01.012

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (1): 46-50.DOI: 10.13701/j.cnki.kqyxyj.2020.01.012

趋化因子受体CXCR7在牙周炎中的表达及其作用机制

张研¹, 辛琪^2*, 马喆², 魏蓉³, 李晓冬⁴, 苏瑞¹, 张源¹

1. 天津市口腔医院牙周科天津 300041;
2. 天津市第三中心医院病理科天津 300170;
3. 南开大学天津 300071;
4. 牡丹江市第一人民医院检验科黑龙江牡丹江 157011

收稿日期:2019-03-24 出版日期:2020-01-28 发布日期:2020-01-16
通讯作者: 辛琪,E-mail:xinqi19820204@126.com
作者简介:张研(1980~ ),男,河北深泽人,硕士, 副主任医师,研究方向:牙周再生治疗。
基金资助:
国家自然科学基金孵育项目(No.2017YNY3)

Expression of Chemokine Receptor CXCR7 in Periodontitis and Its Mechanism

ZHANG Yan¹, XIN Qi^2*, MA Zhe², WEI Rong³, LI Xiaodong³, SU Rui¹, ZHANG Yuan¹

1. Department of Periodontology, Tianjin Stomatology Hospital, Tianjin 300041, China;
2. Department of Pathology, Third Central Hospital of Tianjin, Tianjin 300170, China;
3. Nankai University, Tianjin 300071, China;
4. Department of Clinical Laboratory, Mudanjiang First People's Hospital, Mudanjiang 157011, China.

Received:2019-03-24 Online:2020-01-28 Published:2020-01-16

摘要/Abstract

摘要： 目的:探讨CXCR7在牙周炎中的表达、分布及SDF-1/CXCR7生物学轴在牙周炎中的作用。方法:运用免疫组化的方法检测SDF-1、CXCR4、CXCR7在15例正常的牙龈组织和15例牙周炎组织中的表达,同时运用PCR方法检测15例正常的牙龈组织和15例牙周炎组织中的表达情况。结果:免疫组化和PCR的结果均显示SDF-1、CXCR4、CXCR7在牙周炎组织中表达增高,高于正常牙龈组织(P＜0.05)。SDF-1与CXCR7呈正相关关系(γ=0.533,P=0.041)。CXCR4和CXCR7的表达呈正相关关系(γ=0.533,P=0.041)。结论:CXCR7在牙周炎微环境中的不同细胞群过表达,在牙周炎的病理过程中发挥作用,可能是治疗牙周炎的一个新的作用靶点。

关键词: SDF-1, CXCR4, CXCR7, 牙周炎

Abstract: Objective: To investigate the expression and distribution of CXCR7 in periodontitis and the role of SDF-1/CXCR7 biological axis in periodontitis. Methods: Immunohistochemical method and PCR were used to detect the expression of SDF-1, CXCR4, and CXCR7 in 15 normal gingival tissues and 15 periodontitis tissues. Results: The expressions of SDF-1, CXCR4, and CXCR7 in periodontitis tissues were higher than those in normal gingival tissues (P<0.05). There was a positive correlation between SDF-1 and CXCR7 (γ=0.533, P=0.041), and between CXCR4 and CXCR7 (γ=0.533, P=0.033,P<0.01). CXCR7 was expressed in inflammatory cells of periodontitis and vascular endothelial cells associated with inflammation. Conclusion: The overexpression of CXCR7 in the microenvironment of periodontitis may play a role in the pathological process of periodontitis, which may be a new target for the treatment of periodontitis.

Key words: SDF-1, CXCR4, CXCR7, periodontitis

张研, 辛琪, 马喆, 魏蓉, 李晓冬, 苏瑞, 张源. 趋化因子受体CXCR7在牙周炎中的表达及其作用机制[J]. 口腔医学研究, 2020, 36(1): 46-50.

ZHANG Yan, XIN Qi, MA Zhe, WEI Rong, LI Xiaodong, SU Rui, ZHANG Yuan. Expression of Chemokine Receptor CXCR7 in Periodontitis and Its Mechanism[J]. Journal of Oral Science Research, 2020, 36(1): 46-50.

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趋化因子受体CXCR7在牙周炎中的表达及其作用机制

Expression of Chemokine Receptor CXCR7 in Periodontitis and Its Mechanism

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