牙周治疗对伴慢性牙周炎冠心病患者血清C反应蛋白的影响——循证医学分析

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (3): 242-246.

牙周治疗对伴慢性牙周炎冠心病患者血清C反应蛋白的影响——循证医学分析

肖燕^*, 刘冰, 朱娟芳, 李文鹿, 杨艳杰, 刘林

郑州大学第一附属医院口腔医学中心牙体牙髓牙周科河南郑州 450052

收稿日期:2014-11-14 出版日期:2015-03-28 发布日期:2016-04-29
通讯作者: 肖燕,电话:0371-67966091
作者简介:肖燕(1974~ ),女,河南郑州人,博士在读,副主任医师,主要从事口腔牙周病学临床及基础的研究及教学工作。
基金资助:
国家青年自然科学基金(编号:81402578);河南省教育厅基础前沿(编号:132300410426)

Effects of Periodontal Therapy on Serum C-reactive Protein in CHD Patients with Chronic Periodontitis: A Systematic Review.

XIAO Yan, LIU Bing, ZHU Juan-fang, et al.

Department of Endodontics and Periodontics,Center of Stomatolagy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052

Received:2014-11-14 Online:2015-03-28 Published:2016-04-29

摘要/Abstract

摘要： 目的:从循证医学的角度评价国内牙周治疗对伴慢性牙周炎冠心病患者血清C反应蛋白的影响及其研究质量。方法:计算机检索中国知网(CNKI)、万方数据库、维普数据库(VIP)和中国医学生物资料数据库(CBM),检索时限为1994~2013年,收集发表的所有关于牙周治疗对伴慢性牙周炎冠心病患者血清C反应蛋白影响的文献,按照纳入和排除标准进行文献筛选、资料提取,并依据循证医学的方法进行分析。结果:共检索到15篇符合纳入标准的论著。随机对照试验(randomized controlled trial, RCT) 论著数量较少,研究质量不高,无法进行Meta分析。分析结果显示:就目前而言,牙周治疗可以降低伴慢性牙周炎冠心病患者血清C反应蛋白水平。结论:目前在牙周治疗影响伴慢性牙周炎冠心病患者血清C反应蛋白水平方面的研究较少,质量较低,不能为其对该因子的影响提供最佳证据。临床中需要更多的、科学严谨的RCT研究类的文献,指导牙周治疗对伴慢性牙周炎冠心病患者血清C反应蛋白的影响。

关键词: 慢性牙周炎, 冠心病, 牙周治疗, C反应蛋白, 循证医学

Abstract: Objective: To determine the effectiveness of periodontal therapy on serum C-reactive protein in CHD patients with chronic periodontitis reported by articles and to assess the quality of the studies by evidence-based medicine(EBM). Methods: The databases such as CNKI, wanfangdata, VIP, CBM published from the 1994 to 2013 were searched. All published literatures about the effectiveness of periodontal therapy on serum C-reactive protein in CHD patients with chronic periodontitis were collected. Literatures were screening and the data were extracted in accordance with inclusion criteria. Literature based on evidence-based medicine was analysed. Results: There were totally 15 articles that met the criteria. Randomized controlled trials (RCT) was in a small number and low research quality. Meta-analysis could not be done. The results showed that: for now, periodontal therapy may reduce the levels of serum C-reactive protein in CHD patients with chronic periodontitis. Conclusion: There are not enough articles about the effectiveness of periodontal therapy on serum C-reactive protein in CHD patients with chronic periodontitis. The quantity and quality of the reviewed studies are far from satisfaction and can not meet the clinical needs. Further trials of high methodological quality need to be undertaken in order to guide the effectiveness of periodontal therapy on serum C-reactive protein in CHD patients with chronic periodontitis.

Key words: Chronic periodontitis, CHD, Periodontal therapy , C-reactive protein, Evidence-based medicine

中图分类号:

R781.4

肖燕, 刘冰, 朱娟芳, 李文鹿, 杨艳杰, 刘林. 牙周治疗对伴慢性牙周炎冠心病患者血清C反应蛋白的影响——循证医学分析[J]. 口腔医学研究, 2015, 31(3): 242-246.

XIAO Yan, LIU Bing, ZHU Juan-fang, et al.. Effects of Periodontal Therapy on Serum C-reactive Protein in CHD Patients with Chronic Periodontitis: A Systematic Review.[J]. Journal of Oral Science Research, 2015, 31(3): 242-246.

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