Effect of rhTNFR:Fc on the Osseointegration of Peri-implantitis in Rabbit Model

doi:10.13701/j.cnki.kqyxyj.2016.09.006

Abstract

Abstract: Objective: To evaluate the effect of recombinant human tumour necrosis factor FC fusion protein (rhTNFR:Fc) on the osseointegration of non-surgical treatment peri-implantitis in a rabbit model. Methods: Twelve male adult rabbits were randomly chosen and divided into experimental group and control group. Peri-implantitis of micro implant in rabbit model was induced by securing silk ligatures around the implants in mandibular toothless alveolar for 8 weeks. Experimental group received rhTNFR:Fc (1.1mg/kg daily for 1 week) and control group received saline. Immunohistochemistry was applied to measure the TNF-α level after the application of rhTNFR:Fc; Cone beam CT and McNeal's staining were applied to evaluate the bone resorption and bone repair at the Implant-Bone interface. Results: Compared to control group, TNF-α in experimental group was significantly lower (P<0.05); Bone resorption was significantly decreased after application of rhTNFR:Fc. Conclusion: rhTNFR:Fc reduced tumour necrosis factor level and might contribute to the osseointegration of peri-implantitis.

Key words: rhTNFR:Fc, Peri-implantitis, Tumor necrosis factor-α, Bone resorption, Bone repair

CLC Number:

R781.4

MA Guo-wu , ZHENG Sheng. Effect of rhTNFR:Fc on the Osseointegration of Peri-implantitis in Rabbit Model[J]. Journal of Oral Science Research, 2016, 32(9): 916-919.

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