Analysis of Saliva Metabolic Profile of Patients with Periodontitis using 1H NMR Metabolomics Method.

doi:10.13701/j.cnki.kqyxyj.2017.04.016

Abstract

Abstract: Objective:To discover the distinguishing metabolites in saliva of patients with periodontitis using 1H NMR-based metabolomics method. Methods:The subjects were selected as the experimental group and the control group by blood routine test. The saliva was collected and nuclear magnetic resonance was performed to identify the different metabolic profiles. The metabolites with VIP>1 and univariate statistic P<0.05 were identified as the ultimate distinguishing metabolites. Results: The metabolites glucose, threonine, and leucine were identified as potential indicators of periodontal inflammation. Conclusion: The metabolomics method has the potential to facilitate the screening and early diagnosis of periodontitis.

Key words: Periodontitis, Saliva , Metabolomics , Nuclear magnetic resonance (NMR)

CLC Number:

R781.4

WANG Hui, KU Li-bo, XU Guo-quan, ZHAO Zhi-hua, MA Li.. Analysis of Saliva Metabolic Profile of Patients with Periodontitis using 1H NMR Metabolomics Method.[J]. Journal of Oral Science Research, 2017, 33(4): 412-415.

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