Abstract: Objective: To evaluate the validity of navigation guide in the treatment of oral and maxillofacial tumor adjacent to skull base. Methods: From 2015 to 2017, 15 patients with oral and maxillofacial tumor adjacent to skull base were collected in Nanjing Stomatological Hospital, including 3 cases of adenoid cystic carcinoma of the palate, 3 cases of parotid tumor, 2 cases of maxillary gingival carcinoma, 2 cases of maxillary sinus carcinoma, 1 cases of palatal carcinoma, 1 cases of maxillary mucoepidermoid carcinoma, 1 cases of left maxillary myxofibroma,1 cases of the left oropharyngeal cancer recurrence, and 1 cases of recurrent right glenoid fossa and skull osteoma after operation. All surgeries were performed under the guidance of AccuNavi-A navigation system to explicit the surgical approach and the boundary of tumor. The accuracy of surgery was evaluated via the pathological margin, nerve protection, vascular injury, and integrity of tumor resection. Results: In all cases, under the guidance of navigation, 5 benign tumors resection were performed successfully, and in 10 cases of malignant tumors, 7 cases had upper margin margins, and 3 lesions were positive at the upper margin. Conclusion: Application of computer navigation technology can accurately locate near skull base tumor and important neurovascular structures, which demonstrates great value in significantly improving the resection integrity and completeness of tumor, reducing the complications related to the operation, and ensuring the operation safety.

Key words: Computer assisted navigation, Skull base, Oral and maxillofacial surgery, Safety