Characteristics of Mandibular Cortical Bone Thickness in Type 1 Diabetic Mice

doi:10.13701/j.cnki.kqyxyj.2018.06.011

Abstract

Abstract: Objective: To observe the mandible cortical bone thickness changes in type 1 diabetes mellitus mice using Micro-CT. Methods: Twenty 6-week-old mice were randomly divided into control group and diabetes mellitus group. The diabetes mellitus group received intraperitoneal injection of 50 mg/kg streptozotocin for 5 days to establish a type 1 diabetes mellitus model, and the control group received intraperitoneal injection of citrate buffer. Then the mice were sacrificed after 12 weeks. The serum calcium and serum phosphorus levels were detected. Micro-CT technique was used to observe the cortical bone thickness changes of the mandible in type 1 diabetes mellitus mice and control group. Results: Compared with control group, the serum calcium level in diabetes mellitus group was decreased, the serum phosphorus level was increased, and the calcium-phosphorus product level was decreased significantly. Micro-CT showed that the thickness of mandible cortical bone in the interest region of type 1 diabetes mellitus mice was significantly decreased in contrast to that of control group (P<0.01). Conclusion: The streptozotocin -induced type 1 diabetes mellitus mice model suggested that the three-dimensional structure of the cortical bone were changed significantly. Micro-CT showed the thickness change of the cortical bone was more obvious.

Key words: Diabetes, Micro-CT, Cortical bone, Bone microstructure

SU Ye , SHAO Ling. Characteristics of Mandibular Cortical Bone Thickness in Type 1 Diabetic Mice[J]. Journal of Oral Science Research, 2018, 34(6): 619-622.

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