Research Progress on Mechanism of Protein Tyrosine Phosphatase Regulating Osteoclast

doi:10.13701/j.cnki.kqyxyj.2021.09.002

Abstract

Abstract: Osteoclastic protein-tyrosine phosphatase (PTP-oc) is a protein tyrosine phosphatase specifically expressed in osteoclasts and osteoclast precursor cells, which is involved in the regulation of biological behavior of osteoclasts through a variety of mechanisms. In this paper, the mechanism of PTP-oc in regulating activity, differentiation, and adhesion of osteoclast was summarized, which provides reference for further study on the role of PTP-oc, and also provides some evidence for the prevention and treatment of root resorption in the process of orthodontics tooth movement with PTP-oc as the target.

Key words: protein tyrosine phosphatase, osteoclasts, mechanism of action

ZHANG Fan, JIANG Huan. Research Progress on Mechanism of Protein Tyrosine Phosphatase Regulating Osteoclast[J]. Journal of Oral Science Research, 2021, 37(9): 780-782.

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