Mechanisms of Parathyroid Hormone Related Protein in Growth and Development of Mandibular Condylar Cartilage:A Review

doi:10.13701/j.cnki.kqyxyj.2021.09.005

Abstract

Abstract: Mandibular condylar cartilage is a secondary fibrocartilage, the regulation of which may be more complex. Only in the last decade or so has there been a growing body of research on the growth and development of condylar cartilage, both in China and abroad. Parathyroid hormone related protein (PTHrP) is a key regulator of cartilage metabolism and is widely involved in the process of cartilage growth and remodeling, morphogenesis, and osteogenesis within the cartilage. Similar to limb cartilages, PTHrP plays a key role in the growth and development of mandibular condylar cartilage. Deeply understanding the regulatory mechanism of PTHrP signaling and related factors during the development of condylar cartilage can further clarify the effect of PTHrP on the growth and development of temporomandibular joint, which has important guiding significance for clinical diagnosis and treatment. This article reviews the mechanism of PTHrP in the growth and development of mandibular condylar cartilage.

Key words: parathyroid hormone related protein, temporomandibular joint, condylar cartilage, mechanism

ZHUANG Qianzhi, WU Xiuping. Mechanisms of Parathyroid Hormone Related Protein in Growth and Development of Mandibular Condylar Cartilage:A Review[J]. Journal of Oral Science Research, 2021, 37(9): 791-793.

References

[1] Deng Z, Liu Y, Wang C, et al. Involvement of PI3K/Akt pathway in rat condylar chondrocytes regulated by PTHrP treatment [J]. Arch Oral Biol, 2014, 59(10):1032-1041.
[2] 刘洪,颜成东,蒋尚飞.甲状旁腺素相关肽核定位序列和C-末端缺失对小鼠下颌骨发育的影响[J].口腔医学研究,2017,33(10):1044-1047.
[3] Lai NK, Martinez D. Physiological roles of parathyroid hormone-related protein [J]. Acta Biomed, 2019, 90(4):510-516.
[4] Frieling JS, Lynch CC. Proteolytic regulation of parathyroid hormone-related protein: functional implications for skeletal malignancy [J]. Int J Mol Sci, 2019, 20(11):2814.
[5] 熊红珍,徐会勇,李松.甲状旁腺激素相关蛋白mRNA在髁突软骨与生长板软骨发育早期的表达变化[J].广东牙病防治,2012,20(8):409-412.
[6] Ishii-Suzuki M, Suda N, Yamazaki K, et al. Differential responses to parathyroid hormone-related protein (PTHrP) deficiency in the various craniofacial cartilages [J]. Anat Rec, 1999, 255(4):452-457.
[7] 李江宁,陈扬熙.功能矫治前伸大鼠下颌髁突中甲状旁腺相关蛋白(PTHrP)基因表达的季节性变化规律[J].现代口腔医学杂志,2005,19(6):38-41.
[8] Kronenberg HM. Developmental regulation of the growth plate [J]. Nature, 2003, 423(6937):332-336.
[9] Datta NS, Abou-Samra AB. PTH and PTHrP signaling in osteoblasts [J]. Cell Signal, 2009, 21(8):1245-1254.
[10] 阎帆,冯剑颖,刘晨燕,等.不同咀嚼负荷对幼兔髁突软骨内印度豪猪蛋白-人甲状旁腺激素相关蛋白通路表达的影响[J].华西口腔医学杂志,2017,35(2):127-132.
[11] Giordano C, Ruel L, Poux C, et al. Protein association changes in the Hedgehog signaling complex mediate differential signaling strength [J]. Development, 2018, 145(24):dev166850.
[12] Jahan E, Matsumoto A, Rafiq AM, et al. Fetal jaw movement affects Ihh signaling in mandibular condylar cartilage development: the possible role of Ihh as mechanotransduction mediator [J]. Arch Oral Biol, 2014, 59(10):1108-1118.
[13] Kaul R, O'Brien MH, Dutra E, et al. The effect of altered loading on mandibular condylar cartilage [J]. PLoS One, 2016,11(7):e0160121.
[14] Huang L, Cai X, Li H, et al. The effects of static pressure on chondrogenic and osteogenic differentiation in condylar chondrocytes from temporomandibular joint [J]. Arch Oral Biol, 2015, 60(4):622-630.
[15] Zieba JT, Chen YT, Lee BH, et al. Notch signaling in skeletal development, homeostasis and pathogenesis [J]. Biomolecules, 2020, 10(2):332.
[16] Serrano MJ, So S, Hinton RJ. Roles of notch signalling in mandibular condylar cartilage [J]. Arch Oral Biol, 2014, 59(7):735-740.
[17] Liu QH, Liao LM, Wu H, et al. PTH promotes rabbit tibial fracture healing via the Notch signaling pathway [J]. Eur Rev Med Pharmacol Sci, 2020, 24(4):1616-1623.
[18] Deng B, Yang X, Liu J, et al. Focal adhesion kinase mediates TGF-beta1-induced renal tubular epithelial-to-mesenchymal transition in vitro [J]. Mol Cell Biochem, 2010, 340(1-2):21-29.
[19] Sun W, Wu J, Huang L, et al. PTHrP nuclear localization and carboxyl terminus sequences modulate dental and mandibular development in part via the action of p27 [J]. Endocrinology, 2016, 157(4):1372-1384.
[20] Shi Z, Lv J, Xiaoyu L, et al. Condylar degradation from decreased occlusal loading following masticatory muscle atrophy [J]. Biomed Res Int, 2018, 2018:6947612.
[21] Cao X, Duan Z, Yan Z, et al. miR-195 contributes to human osteoarthritis via targeting PTHrP [J]. J Bone Miner Metab, 2019, 37(4):711-721.
[22] Duan ZX, Huang P, Tu C, et al. MicroRNA-15a-5p regulates the development of osteoarthritis by targeting PTHrP in chondrocytes [J]. Biomed Res Int, 2019, 2019:3904923.