Expression of Hypoxia Inducible Factor-1α in Periodontal Tissues of Diabetic Patients with Periodontitis and Its Relationship with Gingival Microcirculation Disorder

doi:10.13701/j.cnki.kqyxyj.2024.02.005

Abstract

Abstract: Objective: To investigate the expression characteristics of hypoxia inducible factor-1α (HIF-1α) in periodontal tissues of diabetic patients with periodontitis and the relationship between HIF-1α and gingival microcirculation parameters. Methods: A total of 237 patients with type 2 diabetes who were treated in our hospital from March 2019 to March 2022 were selected as the study objects. According to whether the patients had periodontitis or not, they were divided into the group with periodontitis (105 cases) and the group without periodontitis (132 cases). Logistic regression model was used to analyze the relationship between the expression level of HIF-1α and the risk of periodontitis in diabetic patients. The dose-response relationship between HIF-1α and periodontitis was analyzed by restricted cubic spline model. Multivariate logistic regression analysis was used to analyze the factors affecting the occurrence of periodontitis in diabetic patients. The interaction of HIF-1α and gingival microcirculation parameters was analyzed by Cox regression. The structural equation prediction model was established and verified. Results: After adjusting for confounding factors, HIF-1α was positively correlated with periodontitis in diabetic patients. The expression level of HIF-1α was not nonlinear dose-response related to diabetic patients with periodontitis, and was not related to gender. HIF-1α and gingival microcirculation parameters were important factors affecting the occurrence of periodontitis. The interaction of HIF-1α and gingival microcirculation parameters might increase the risk of periodontitis in diabetic patients. The interaction effect of HIF-1α combined with gingival blood flow was the highest. The overall adaptation of structural equation model was better, which could reflect the relationship between the influencing factors and the occurrence of periodontitis. The prediction model had good differentiation and independence. Conclusion: HIF-1α is a risk factor for periodontitis in diabetic patients. The interaction of HIF-1α and gingival microcirculation parameters may increase the risk of periodontitis in diabetic patients.

Key words: type 2 diabetes, periodontitis, hypoxia inducing factor-1α, gingival microcirculation, periodontal tissue

FENG Jiafei, XIE Bing. Expression of Hypoxia Inducible Factor-1α in Periodontal Tissues of Diabetic Patients with Periodontitis and Its Relationship with Gingival Microcirculation Disorder[J]. Journal of Oral Science Research, 2024, 40(2): 118-124.

References

[1] 糖尿病肾病多学科诊治与管理共识专家组.糖尿病肾病多学科诊治与管理专家共识[J].全科医学临床与教育,2020,18(6):484-487.
[2] Caton JG, Armitage G, Berglundh T, et al. A new classification scheme for periodontal and peri-implant diseases and conditionsIntroduction and key changes from the classificatio [J]. Clin Periodontol, 2020, 3(6): 123-125.
[3] 李晶,王勤涛.血管内皮生长因子在牙周组织中的表达及其作用[J].国际口腔医学杂志, 2021,41(4):455-458.
[4] 全茂伟,杨香菊,魏燕,等.牙周基础治疗对中、重度牙周炎患者血脂和血清炎性因子、超敏C反应蛋白的影响[J].实用口腔医学杂志,2020,35(2):94-98.
[5] Liljestrand JM, Havulinna AS, Paju S, et al. Missing teeth predict incident cardiovascular events, diabetes, and death [J]. J Dent Res, 2021, 94(8):1055-1062.
[6] 谢倩倩,高秀秋,张超.慢性牙周炎合并2型糖尿病患者龈沟液内脂素水平检测及临床意义[J].陕西医学杂志,2021,50(2):233-235.
[7] Marzal M, Guerragiraldez C, Paredes A, et al. Evans blue staining reveals vascular leakage associated with focal areas of host-parasite interaction in brains of pigs infected with Taenia solium [J]. PLoS One, 2021, 9(6):973-978.
[8] 贾旭贝,贾旭朝.牙周基础治疗对2型糖尿病伴牙周炎患者的疗效[J].糖尿病天地,2021,17(7):109-110.
[9] Iannella G, Di Gioia C, Carletti R, et al. Tympanomastoid cholesterol granulomas: Immunohistochemical evaluation of angiogenesis [J]. Laryngoscope, 2020, 127(8):283-290.
[10] Shi GJ, Shi G, Zhou JY, et al. Involvement of growth factors in diabetes mellitus and its complications: A general review [J]. Biomed Pharmacother, 2020, 101(5):510-527.
[11] Wang F, Guo X, Shen X, et al. Vascular dysfunction associated with type 2 diabetes and Alzheimer s disease: a potentialetiological linkage [J]. Med Sci Monit Basic Res, 2021, 20(10):124-129.
[12] 张冬雪,林梅,周璿,等.牙周状况对糖尿病肾病患者血糖控制的影响[J].首都医科大学学报,2021,42(2): 306-311.
[13] Leite FRM, Nascimento GG, Scheutz F, et al. Effect of smoking on periodontitis: a systematic review and metaregression [J]. Am J Prev Med, 2021, 54(6): 831-841.
[14] Prakash P, Rath S, Mukherjee M, et al. Comparative evaluation of the marginal gingival epithelium in smokers and nonsmokers: a histomorphometric and immunohistochemical study [J]. Int J Periodontics Restorative Dent, 2022, 34(6):781-786.
[15] Park HS, Cho K, Park YJ, et al. Chronic nicotine exposure attenuates proangiogenic activity on human umbilical vein endothelial cells [J]. J Cardiovasc Pharmacol, 2021, 57(3): 287-293.
[16] Jalayer Naderi N, Semyari H, Elahinia Z. The impact of smoking on gingiva: a histopathological study [J]. Iran J Pathol, 2022, 10(3): 214-220.
[17] Decarvalhoj AM, Mastella AK, Stein CS, et al. Periodontitis and hypertension: is the association causal [J]. High Blood Press Cardiovasc Prev, 2020, 27(4): 281-289.
[18] Ma RCW. Epidemiology of diabetes and diabetic complicationsin China [J]. Diabetologia, 2018, 61(6):1249-1260.