Potential Role of Concentrated Growth Factor on Healing of Mature Permanent Teeth Periapical Inflammation of Beagle Dogs

doi:10.13701/j.cnki.kqyxyj.2023.07.007

Abstract

Abstract: Objective: To investigate the potential effect of concentrated growth factor (CGF) combined with revascularization on the healing of mature permanent teeth periapical inflammation of Beagle dogs. Methods: Thirty-six mandibular incisors from six 18-month-old Beagle dogs were selected and divided into four groups. The teeth in positive control group were not intervened. The teeth in negative group were established periapical periodontitis models and not treated. The teeth in revascularization group were established periapical periodontitis models and treated with revascularization. The teeth in revascularization combined with CGF group were established periapical periodontitis models and treated with CGF combined with revascularization. X-ray apical radiographs were taken after surgery, and the histological changes of the experimental teeth in various groups were observed by HE staining. Results: The periapical periodontitis model of Beagle dogs was established successfully. In revascularization group and revascularization combined with CGF group, periapical shadows were reduced. Mineralized tissue could be seen in the apical, and bone lacuna could be seen in the mineralized tissue, but the mineralized tissue in the group of revascularization combined with CGF was more dense. Conclusion: CGF combined with revascularization has potential effect to promote the periapical periodontitis healing of mature permanent teeth of Beagle dogs.

Key words: concentrated growth factors, periapical periodontitis, mature permanent teeth, dental pulp regeneration

WANG Jing, LIN Huajie, HUANG Wei, YIN Jinping, MENG Weitao, ZHANG Xiaoya. Potential Role of Concentrated Growth Factor on Healing of Mature Permanent Teeth Periapical Inflammation of Beagle Dogs[J]. Journal of Oral Science Research, 2023, 39(7): 602-606.

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