Clinical Application of Concentrated Growth Factors in Guided Bone Regeneration of Maxillary Anterior Region

doi:10.13701/j.cnki.kqyxyj.2019.07.014

Abstract

Abstract: Objective: To evaluate the clinical effect of guided bone regeneration by using concentrated growth factors (CGF) in maxillary anterior region. Methods: 65 patients with single anterior tooth labial bone defect were enrolled and randomly divided into experimental group (32 cases) and control group (31 cases). The experimental group was treated with CGF combined with Bio-oss and covered with CGF membrane, and the control group was treated with Bio-oss and covered with biological membrane. Cone beam computed tomography (CBCT) was performed at baseline, immediate, and 6 months post-surgery, and the keratinized gingiva width was measured at baseline and 6 months post-surgery. The changes of clinical and CBCT data were compared between two groups. Results: There was a statistically significant increase in the horizontal bone width in both groups between baseline and post-surgery (P＜0.01) . Six months postoperatively, the gain of horizontal bone in the experimental groups was significantly higher than that in the control group (P＜0.05). The test group showed statistically significantly lower bone absorption rate than the control group (P＜0.05). Six months after operation, there was a statistically significant increase in the keratinized gingiva width in the experimental group compared with baseline (P＜0.05), however, there were no changes in the control group (P＞0.05). Conclusion: The application of CGF in guided bone regeneration of maxillary anterior region showed better effect on the regeneration of the soft and hard tissue.

Key words: concentrated growth factors, guided bone regeneration , regeneration of the soft and hard tissue, alveolar ridge augmentation

YU Wenfeng, ZHAO Shijun, LV Minmin, CUI Fenglin, KANG Meizhen, ZHANG Zhiyuan. Clinical Application of Concentrated Growth Factors in Guided Bone Regeneration of Maxillary Anterior Region[J]. Journal of Oral Science Research, 2019, 35(7): 676-680.

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