Research Progress of Oral Local Drug Delivery System in Treatment of Periodontitis:A Literature Review

doi:10.13701/j.cnki.kqyxyj.2025.06.002

Abstract

Abstract: As a commonly and frequently occurred chronic infectious disease, periodontitis has become the main cause of teeth loss in adults. Nowadays, the clinical treatment of periodontitis is mainly based on non-surgical mechanical treatment: scaling and root planting (SRP). But the particular oral anatomy has increased the difficulty of mechanical treatment, which makes drug application an important adjunctive treatment. In recent years, local drug delivery system (LDDS) has gradually become the mainstream for its convenient use, sustain-release, control-release, targeted effect, and low side effects. Especially for various oral diseases, oral LDDS has become a hotspot in the treatment. This paper reviews these emerged oral LDDS: fibers, strips, films, gel, microspheres, nanoparticles, and gene engineering materials.

Key words: periodontitis, drug delivery system, microspheres, nanoparticles, gene engineering

DU Lan, CHEN Liang. Research Progress of Oral Local Drug Delivery System in Treatment of Periodontitis:A Literature Review[J]. Journal of Oral Science Research, 2025, 41(6): 457-462.

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