An Experimental Study of Bio-oss with HIF-1α Protein on Tooth Extraction Bone Healing.

Abstract

Abstract: Objective: To study Bio-oss bone with HIF-1α protein on tooth extraction bone healing. Methods: Under general anesthesia, mesial root of the 2nd, 4th premolars in both sides of mandible of 3 Beagle dogs were extracted. Randomly, a wound was selected as the blank control group, and the rest were immediately implanted bio-oss, bio-oss with HIF-1α protein of 100ng/ml. After six and twelve weeks, the beagle dogs were sacrificed. The gross speciments were examined by Micro-CT images, and mineralized specimen preparations were prepared. Results: Micro-CT scan analysis showed that each group had some differences in the number of trabecular, bone mineral density and BV/TV. After twelve weeks,bio-oss with HIF-1α group was significantly higher than the bio-oss group、 the control group (P<0.05). The difference was statistical significance. Tissue slides also revealed an effective osteogensis in those wounds implanted with bio-oss with HIF-1α. Conclusion: Bio-oss with HIF-1α protein l can promote the regeneration of alveolar bone.

Key words: Bio-oss , HIF-1α protein, Tooth extraction, Bone healing

CLC Number:

R782.1

TAN Luan-jun, RUAN Zheng, ZHANG Jin-e, et al.. An Experimental Study of Bio-oss with HIF-1α Protein on Tooth Extraction Bone Healing.[J]. Journal of Oral Science Research, 2015, 31(5): 441-443.

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