Abstract: Objective: To evaluate the effects of three desensitizers on bond strength of zirconia ceramic. Methods: Freshly extracted human premolars were exposed dentinal tubules. Three desensitizers(Hybrid Coat, Adper Easy One, Duraphat suspension) were used in corresponding groups by different time. Zirconia ceramic slices were bonded to dentine surfaces with resin-modified glass ionomer cements (RMBIC) and resin cements (RC) respectively. The prepared teeth without desensitizer were used as control group. Specimens were tested by a universal testing machine to obtain the shear bond strength of each specimen and measured micro leakage by magenta-staining method . The value was analyzed by SPSS 19.0 statistical software. Results: The difference of shear strength value between Hybrid Coat group and the control group had no statistical significance; The shear strength value of Adper Easy One group was higher than the control group (P<0.05); The shear strength value of Duraphat group was lower than the control group (P<0.05); The shear strength value of after preparatory group was higher than prior bonding group (P<0.05). RMGIC showed greater strength than RC (P<0.05). Conclusion: Hybrid Coat and Adper Easy One could be chosen for desensitization when bonding zirconia ceramic restoration desensitize should be used after vital pulp abutment teeth preparation to reduce the postoperative sensitivity and enhance the bond strength of dentin interface. The bond strength of RC is higher than RMGIC.

Key words: Dentine hypersensitivity, Desensitizer, Cements, Shear bond strength